{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:46:46Z","timestamp":1791974806163,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Restoring bone marrow microenvironment (BMM) homeostasis is critical for fracture healing, yet non\u2010invasively tracking physiological events like apoptosis, angiogenesis and matrix remodelling remains challenging. This study evaluated multiparametric 7.0T MRI (T2 mapping and proton density\u2010weighted imaging [PDWI]) for in\u00a0vivo tracking of BMM spatiotemporal remodelling during natural and pharmacologically accelerated bone repair. Utilizing a rat tibial drill\u2010hole injury model (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200936), we compared a natural healing control with a Huoxue Qiangji Decoction (HQD) intervention group. Serial high\u2010resolution sagittal MRIs were acquired at days 7, 14 and 21, with signal intensity ratios (SIR) normalized to ipsilateral intact marrow using ITK\u2010SNAP. Distance correlation (dCor) analysis explored non\u2010linear dependencies between MRI metrics and histological features (c\u2010cas3, Masson's trichrome and day\u201014 CD31\/Ki67 expression). Results showed distinct MRI signal trajectories, with earlier homeostatic stabilization in the accelerated healing group. Spatiotemporal mapping revealed closely mirrored non\u2010linear dependencies between MRI and histology. Specifically, T2 mapping SIR mirrored early\u2010stage apoptosis (dCor\u2009=\u20090.527) and mid\u2010term cellular proliferation (Ki67, dCor\u2009=\u20090.732). Concurrently, PDWI reflected dynamic trends of mid\u2010term angiogenesis (CD31, dCor\u2009=\u20090.637) and late\u2010stage collagen deposition (dCor\u2009=\u20090.480). In conclusion, normalized multiparametric MRI provides complementary macroscopic insights into BMM histological progression, highlighting its potential as an objective, non\u2010invasive translational tool for monitoring musculoskeletal healing.\n                  <\/jats:p>","DOI":"10.1111\/ahe.70181","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:01:40Z","timestamp":1791972100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serial Cross\u2010Sectional Mapping of Bone Marrow Microenvironment Remodelling During Fracture Repair Using Multiparametric\n                    <scp>MRI<\/scp>\n                    and Histopathology"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8818-3384","authenticated-orcid":false,"given":"Rui","family":"Zhou","sequence":"first","affiliation":[{"name":"Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine  Guiyang China"},{"name":"School of Basic Medical Sciences Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochen","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Yao","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyi","family":"Deng","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-3834","authenticated-orcid":false,"given":"Xianchun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Guizhou Provincial People's Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jor.24170","article-title":"Cellular Biology of Fracture Healing","volume":"37","author":"Bahney C. 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L.","year":"2023","journal-title":"Investigative Radiology"},{"issue":"1","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture Healing: Mechanisms and Interventions","volume":"11","author":"Einhorn T. A.","year":"2015","journal-title":"Nature Reviews Rheumatology"},{"issue":"3","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1055\/s-0041-1732334","article-title":"Bone Healing and Inflammation: Principles of Fracture and Repair","volume":"35","author":"ElHawary H.","year":"2021","journal-title":"Seminars in Plastic Surgery"},{"issue":"5","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jcb.10435","article-title":"Fracture Healing as a Post\u2010Natal Developmental Process: Molecular, Spatial, and Temporal Aspects of Its Regulation","volume":"88","author":"Gerstenfeld L. 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