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Several processes are shared between cocaine and heroin addictions but some neurobiological mechanisms may be specific. This study examined the association of 98 single nucleotide polymorphisms in 13 dopamine\u2010related genes with heroin addiction (OD) and\/or cocaine addiction (CD) in a sample of 801 African Americans (315 subjects with OD \u00b1 CD, 279 subjects with CD, and 207 controls). Single\u2010marker analyses provided nominally significant evidence for <jats:italic>associations<\/jats:italic> of 24 SNPs) in <jats:italic>DRD1<\/jats:italic>, <jats:italic>ANKK1\/DRD2<\/jats:italic>, <jats:italic>DRD3<\/jats:italic>, <jats:italic>DRD5, DBH<\/jats:italic>, <jats:italic>DDC, COMT and CSNK1E<\/jats:italic>. A <jats:italic>DRD2<\/jats:italic> 7\u2010SNPs haplotype that includes SNPs rs1075650 and rs2283265, which were shown to alter D2S\/D2L splicing, was indicated in both addictions. The Met allele of the functional <jats:italic>COMT<\/jats:italic> Val158Met was associated with protection from OD. None of the signals remained significant after correction for multiple testing. The study results are in accordance with the results of previous studies, including our report of association of <jats:italic>DRD1<\/jats:italic> SNP rs5326 with OD. The findings suggest the presence of an overlap in genetic susceptibility for OD and CD, as well as shared and distinct susceptibility for OD in subjects of African and European descent.<\/jats:p>","DOI":"10.1111\/ahg.12104","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T13:39:11Z","timestamp":1425044351000},"page":"188-198","source":"Crossref","is-referenced-by-count":33,"title":["Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans"],"prefix":"10.1111","volume":"79","author":[{"given":"Orna","family":"Levran","sequence":"first","affiliation":[{"name":"The Laboratory of the Biology of Addictive Diseases The Rockefeller University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Randesi","sequence":"additional","affiliation":[{"name":"The Laboratory of the Biology of Addictive Diseases The Rockefeller University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Correa","family":"da Rosa","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science The Rockefeller University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurg","family":"Ott","sequence":"additional","affiliation":[{"name":"Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"The Laboratory of Statistical Genetics The Rockefeller University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rotrosen","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare System and NYU School of Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Adelson","sequence":"additional","affiliation":[{"name":"The Laboratory of the Biology of Addictive Diseases The Rockefeller University  New York NY USA"},{"name":"Dr. Miriam and Sheldon G. 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