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The single nucleotide polymorphism (SNP) rs1360780, linked to FK506\u2010binding protein 51 (FKBP5), has been shown to affect HPA axis functioning, and has thus been suggested as a promising candidate for indicating vulnerability to stress\u2010related disorders. The aim of this study was to investigate the interaction between nicotine consumption and rs1360780 on cortisol plasma levels in females. A total of 296 female smokers (assessed by the Fagerstr\u00f6m Test for Nicotine Dependence; FTND) were genotyped for the SNP rs1360780. We measured participants\u2019 cortisol plasma concentration in blood plasma collected 3 h after standardized tobacco smoking exposure. In the 36 <jats:italic>TT\u2010homozygotes<\/jats:italic>, we found a significant negative correlation between the FTND sum score and cortisol plasma concentrations. Using linear regression analysis, we found that the FTND sum score accounted for 12.4% of the variance of cortisol plasma levels. This association was not detected in <jats:italic>C\u2010allele carriers<\/jats:italic>. Our results suggest that nicotine is an important confounder in the modulation of HPA axis activity by FKBP5. In light of these findings, future studies on FKBP5 should seek to include data on nicotine consumption as a covariate.<\/jats:p>","DOI":"10.1111\/ahg.12153","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:27:08Z","timestamp":1460312828000},"page":"154-161","source":"Crossref","is-referenced-by-count":12,"title":["The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the <i>FKBP5<\/i> Genotype"],"prefix":"10.1111","volume":"80","author":[{"given":"Anne","family":"Koopmann","sequence":"first","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Bez","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tagrid","family":"Lemenager","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derik","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Dinter","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rilana","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospital of Hamburg  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Winterer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine Charite Berlin, Charit\u00e9platz 1  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falk","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.81"},{"key":"e_1_2_7_3_1","unstructured":"American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM IV) (1994)1000 Wilson Boulevard Arlington VA 22209 9780890420249 2000."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.05.021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1479"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1291"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09040576"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.12.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.01.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-6-52"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.11.007"},{"key":"e_1_2_7_14_1","unstructured":"Hautzinger M. 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