{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:17:13Z","timestamp":1775078233323,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Top-Notch Yong Talents Program of China"},{"name":"General Program of the National Natural Science Foundation of China","award":["81573035, 81271747"],"award-info":[{"award-number":["81573035, 81271747"]}]},{"DOI":"10.13039\/100014717","name":"National Science Fund for Excellent Young Scholars","doi-asserted-by":"crossref","award":["81222022"],"award-info":[{"award-number":["81222022"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Basic Research Program of China","award":["2012CB722404"],"award-info":[{"award-number":["2012CB722404"]}]},{"name":"Anhui Province Natural Science Foundation Program","award":["1508085JGD05"],"award-info":[{"award-number":["1508085JGD05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Psoriasis vulgaris is a chronic inflammatory skin disease associated with complex genetic susceptibility. Recently, we identified a single\u2010nucleotide variant rs1020760 at <jats:italic>NFKB1<\/jats:italic> significantly associated with psoriasis in a Han Chinese population in deep analysis of exome and targeted sequencing (<jats:italic>P<\/jats:italic> = 1.76 \u00d7 10<jats:sup>\u22128<\/jats:sup>). To investigate the potential association between rs1020760 and phenotypes of psoriasis vulgaris, we performed a genotype\u2013phenotype analysis. A total of 9946 cases and 9906 controls with detailed clinical and demographic information were involved in this study, while the genotype data of rs1020760 was available in the previous targeted sequencing study of psoriasis. Genotype\u2010based association testing revealed the additive model might provide the best fit for rs1020760 (<jats:italic>P<\/jats:italic> = 5.44 \u00d7 10<jats:sup>\u22128<\/jats:sup>). Case\u2010only analysis showed that the distribution of allele G was significantly different between the cases with and without family history (<jats:italic>P<\/jats:italic><jats:sub>allele<\/jats:sub> = 4.07 \u00d7 10<jats:sup>\u22123<\/jats:sup>,<jats:italic>P<\/jats:italic><jats:sub>genotype<\/jats:sub> = 5.75 \u00d7 10<jats:sup>\u22123<\/jats:sup>). The differences in allele and genotype frequencies were observed between all the subphenotypes and controls except for the genotype frequency of the late onset subgroup, while no difference was found in case\u2010only analysis for the other two subphenotypes. Rs1020760 was preferentially associated with family history of psoriasis, implying that <jats:italic>NFKB1<\/jats:italic> might not only play important roles in the development of psoriasis, but might also contribute to the special phenotypes of this disease.<\/jats:p>","DOI":"10.1111\/ahg.12156","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T06:42:10Z","timestamp":1467009730000},"page":"197-202","source":"Crossref","is-referenced-by-count":8,"title":["A Genetic Variant rs1020760at <i>NFKB1<\/i> is Associated with Clinical Features of Psoriasis Vulgaris in a Han Chinese Population"],"prefix":"10.1111","volume":"80","author":[{"given":"Wenjun","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianbo","family":"Zuo","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical 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Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangdan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology at No. 1 Hospital Anhui Medical University  China"},{"name":"Key Laboratory of Dermatology, Anhui Medical University Ministry of Education  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