{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:27:20Z","timestamp":1759991240112},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:00:00Z","timestamp":1468281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U01HL126496\u201002"],"award-info":[{"award-number":["5U01HL126496\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Human life expectancy is influenced not only by longevity assurance mechanisms and disease susceptibility loci but also by the environment, gene\u2013environment interactions, and chance. MicroRNAs (miRNAs) are a class of small noncoding RNAs closely related to genes. Circulating miRNAs have been shown as promising noninvasive biomarkers in the development of many pathophysiological conditions. However, the concentration of miRNA in the circulation may also be affected by environmental factors. We used a next\u2010generation sequencing platform to assess the association of circulating miRNA with life expectancy, for which deaths are due to all causes independent of genes. In addition, we showed that miRNAs are present in 41\u2010year archived plasma samples, which may be useful for both life expectancy and all\u2010cause mortality risk assessment. Plasma miRNAs from nine identical male twins were profiled using next\u2010generation sequencing. The average absolute difference in the minimum life expectancy was 9.68 years. Intraclass correlation coefficients were above 0.4 for 50% of miRNAs. Comparing deceased twins with their alive co\u2010twin brothers, the concentrations were increased for 34 but decreased for 30 miRNAs. Identical twins discordant in life expectancy were dissimilar in the majority of miRNAs, suggesting that environmental factors are pivotal in miRNAs related to life expectancy.<\/jats:p>","DOI":"10.1111\/ahg.12160","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T08:35:14Z","timestamp":1468312514000},"page":"247-256","source":"Crossref","is-referenced-by-count":13,"title":["Circulating MicroRNAs and Life Expectancy Among Identical Twins"],"prefix":"10.1111","volume":"80","author":[{"given":"Shenghui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Medicine The University of Texas Health Science Center at San Antonio  Laredo TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taek\u2010Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Scherler","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baxter","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth E","family":"Krasnow","sequence":"additional","affiliation":[{"name":"Center for Health Sciences, Biosciences Division SRI International  Menlo Park CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Public Health Des Moines University  Des Moines IA USA"},{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Center for Translational and Clinical Cardiovascular Research (VTRACC), Institute of Medicine and Public Health Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1342-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(01)02306-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053928"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1961.10482090"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.226696"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-383"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1947110"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2015.1039517"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.200022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.241190"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030997"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-anchem-071114-040343"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2005-6-4-315"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000176452.17771.20"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1500"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031333"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12236"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370100630"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1994.tb03997.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117207108"},{"key":"e_1_2_8_23_1","unstructured":"SGC. 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