{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:42:01Z","timestamp":1722930121942},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["148522"],"award-info":[{"award-number":["148522"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Common single\u2010nucleotide variation in the host accounts for 25% of the variability in the plasma levels of HIV during the clinical latency stage (viral load set point). However, the role of rare variants and copy number variants remains relatively unexplored. Previous work has suggested copy number variation of a cluster of \u03b2\u2010defensin genes affects HIV load in treatment\u2010na\u00efve sub\u2010Saharan Africans and rate of response to antiretroviral treatment. Here we analyse a total of 1827 individuals from two cohorts of HIV\u2010infected individuals from Europe and sub\u2010Saharan Africa to investigate the role of \u03b2\u2010defensin copy number variation on HIV load at set point. We find no evidence for association of copy number with viral load. We also compare distribution of \u03b2\u2010defensin copy number between European cases and controls and find no differences, arguing against a role of \u03b2\u2010defensin copy number in HIV acquisition. Taken together, our data argue against an effect of copy number variation of the \u03b2\u2010defensin region in the spontaneous control of HIV infection.<\/jats:p>","DOI":"10.1111\/ahg.12182","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T10:29:22Z","timestamp":1484303362000},"page":"27-34","source":"Crossref","is-referenced-by-count":4,"title":["No Evidence for Association of \u03b2\u2010Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS"],"prefix":"10.1111","volume":"81","author":[{"given":"Razan","family":"Abujaber","sequence":"first","affiliation":[{"name":"Department of Genetics University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick R.","family":"Shea","sequence":"additional","affiliation":[{"name":"Institute for Genomic Medicine Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"McLaren","sequence":"additional","affiliation":[{"name":"National HIV and Retrovirology Laboratory Public Health Agency of Canada  Winnipeg Canada"},{"name":"Department of Medical Microbiology and Infectious Diseases University of Manitoba  Winnipeg Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabir","family":"Lakhi","sequence":"additional","affiliation":[{"name":"International AIDS Vaccine Initiative (IAVI)  New York New York USA"},{"name":"Zambia\u2010Emory HIV Research Project  Lusaka and Copperbelt Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Gilmour","sequence":"additional","affiliation":[{"name":"International AIDS Vaccine Initiative (IAVI)  New York New York USA"},{"name":"IAVI Human Immunology Laboratory Imperial College  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Allen","sequence":"additional","affiliation":[{"name":"International AIDS Vaccine Initiative (IAVI)  New York New York USA"},{"name":"School of Life Sciences \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Fellay","sequence":"additional","affiliation":[{"name":"Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Hollox","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"IAVI Africa HIV Prevention Partnership, Swiss HIV Cohort Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-536"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq411"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01838-13"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000012"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1089"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101332"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1009-1112"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22172"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-418"},{"key":"e_1_2_15_11_1","first-page":"161","article-title":"Defensins: natural anti\u2010HIV peptides","volume":"6","author":"Chang T. 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