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We analyzed 53 controls, 86 patients with gastritis, and 19 patients with gastric cancer. Real\u2010time\u2010PCR was used to determine the expression levels of miRNA\u2010146a, miRNA\u2010155, IL\u20102, and TNF\u2010\u03b1. The subsequent analysis of the target genes was performed using the bioinformatics approach. There was no difference in IL\u20102 expression between the groups. However, there was a significant increase in TNF\u2010\u03b1 expression in the gastritis group relative to the control and a significant decrease in the gastric cancer group relative to the control. There was also a statistically significant increase in miRNA\u2010146a and miRNA\u2010155 expression in the gastritis group relative to the control, but not in the gastric cancer group. Similar results were found when the presence of <jats:italic>H. pylori<\/jats:italic> was considered. The data revealed an increase in miRNA\u2010146a and miRNA\u2010155 expression but not enough to control the expression of TNF\u2010\u03b1. The presence of <jats:italic>H. pylori<\/jats:italic> was found to affect increases in TNF\u2010\u03b1 and microRNA expression, and miRNA\u2010146a and miRNA\u2010155 alone were not able to eliminate bacteria or restore tissue homeostasis.<\/jats:p>","DOI":"10.1111\/ahg.12234","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T06:48:35Z","timestamp":1513579715000},"page":"135-142","source":"Crossref","is-referenced-by-count":19,"title":["Expression of miRNA\u2010146a, miRNA\u2010155, IL\u20102, and TNF\u2010\u03b1 in inflammatory response to <i>Helicobacter pylori<\/i> infection associated with cancer progression"],"prefix":"10.1111","volume":"82","author":[{"given":"Luanna Munhoz","family":"Zabaglia","sequence":"first","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara Luciana","family":"Sallas","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Pezenatto Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson Aparecido","family":"Orcini","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita Luiza","family":"Peruquetti","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce Helena","family":"Constantino","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Chen","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia De Arruda Cardoso","family":"Smith","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer\u2010Luiz Marques","family":"Pay\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-2257","authenticated-orcid":false,"given":"Lucas Trevizani","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Universidade do Sagrado Cora\u00e7\u00e3o (USC)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"186","article-title":"Pathogenic mechanisms in Helicobacter pylori infection","volume":"59","author":"Beales I. 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