{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:19:20Z","timestamp":1758709160129,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/02667\u20100"],"award-info":[{"award-number":["2016\/02667\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonsyndromic oral clefts are common congenital birth defects that exhibit variable prevalence around the world, often influenced by population\u2010dependent genetic predisposition. Few studies have been performed with nonsyndromic cleft palate only (NSCPO), limiting the knowledge of the genetic risk factors related to this type of oral cleft. Genetic variants in golgin subfamily B member 1 (<jats:italic>GOLGB1<\/jats:italic>), a gene that is essential for normal murine palatogenesis, were analyzed in this study to establish its potential association with NSCPO risk in the Brazilian population. Five tag\u2010single nucleotide polymorphisms (SNPs) of <jats:italic>GOLGB1<\/jats:italic> (rs1169, rs7153, rs9968051, rs9819530, and rs6794341), which capture the majority of alleles spanning within gene, were genotyped in a case\u2013control study with 270 patients with NSCPO and 284 unrelated healthy controls. The samples were also genotyped for 40 biallelic polymorphic markers to characterize the genetic ancestry. After adjustment for co\u2010variants, the <jats:italic>GOLGB1<\/jats:italic> tag\u2010SNPs and the haplotypes formed by those SNPs were not significantly associated with NSCPO in this Brazilian case\u2013control cohort. Our results suggest that common polymorphisms of <jats:italic>GOLGB1<\/jats:italic> are not associated NSCPO susceptibility in the Brazilian population.<\/jats:p>","DOI":"10.1111\/ahg.12242","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T09:26:35Z","timestamp":1518427595000},"page":"227-231","source":"Crossref","is-referenced-by-count":2,"title":["Association between <i>GOLGB1<\/i> tag\u2010polymorphisms and nonsyndromic cleft palate only in the Brazilian population"],"prefix":"10.1111","volume":"82","author":[{"given":"Renato Assis","family":"Machado","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, School of Dentistry University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herc\u00edlio","family":"Martelli\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Stomatology Clinic, Dental School, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil and Center for Rehabilitation of Craniofacial Anomalies, Dental School University of Jos\u00e9 Rosario Vellano  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Regina","family":"de Almeida Reis","sequence":"additional","affiliation":[{"name":"Department of Basic Science Bahiana School of Medicine and Public Health  Salvador Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene Camati","family":"Persuhn","sequence":"additional","affiliation":[{"name":"Molecular Biology Department Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-3046","authenticated-orcid":false,"given":"Ricardo D.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, School of Dentistry University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35830"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9503.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20595"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00067"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23204"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1669"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37181"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.08.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.134577"},{"key":"e_1_2_8_11_1","first-page":"744","article-title":"A genome\u2010wide association study of nonsyndromic cleft palate identifies an etiologic missense variant in GRHL3","volume":"98","author":"Leslie E. 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