{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:40:39Z","timestamp":1775014839184,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T00:00:00Z","timestamp":1531612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81670290"],"award-info":[{"award-number":["No. 81670290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["No. 2017M622583"],"award-info":[{"award-number":["No. 2017M622583"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myasthenia gravis (MG) is considered to be a kind of autoimmune disorder resulting from dysfunction of neuromuscular transmission caused by autoantibodies against the nicotinic acetylcholine receptors. A number of studies have identified Cytotoxic T\u2010lymphocyte\u2010associated antigen\u20104 (<jats:italic>CTLA\u20104<\/jats:italic>) as a candidate gene for MG. Several recent reports have indicated that single nucleotide polymorphisms (SNPs) of <jats:italic>CTLA\u20104<\/jats:italic>, including rs733618, rs4553808, rs5742909, rs231775, and rs3087243 were associated with the risks of MG; however, the results were not consistent. To assess the correlations between <jats:italic>CTLA\u20104<\/jats:italic> SNPs and MG susceptibility, a meta\u2010analysis was performed following a series of database searching. A total of 1460 cases and 1652 controls from 12 studies were enrolled in the analysis. Our results indicated that rs231775 and rs733618 were associated with higher risks of MG, providing potential references for future case\u2013control studies.<\/jats:p>","DOI":"10.1111\/ahg.12262","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T05:01:03Z","timestamp":1531717263000},"page":"358-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of <i>CTLA\u20104<\/i> polymorphisms with increased risks of myasthenia gravis"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-0926","authenticated-orcid":false,"given":"Fang","family":"Li","sequence":"first","affiliation":[{"name":"The Center for Heart Development, State Key Lab of Development Biology, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences Hunan Normal University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuzhou","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Center for Heart Development, State Key Lab of Development Biology, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences Hunan Normal University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiushan","family":"Wu","sequence":"additional","affiliation":[{"name":"The Center for Heart Development, State Key Lab of Development Biology, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences Hunan Normal University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1352"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20577"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.03.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.05.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8478-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00119-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.270"},{"key":"e_1_2_8_14_1","first-page":"307","article-title":"Correlation between single nucleofide polymorphisms of multi\u2010loci and multi\u2010genes and myasthenia gravis","volume":"49","author":"Kong X.","year":"2016","journal-title":"Chinese Journal of Neurology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363655"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0024-y"},{"key":"e_1_2_8_17_1","first-page":"98","article-title":"Association of single nucleotide polymorphisms of CTLA\u20104 promoter region 1722T\/C with myasthenia gravis","volume":"11","author":"Lin X.","year":"2014","journal-title":"Journal of Medical Molecular Biology"},{"key":"e_1_2_8_18_1","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N.","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"e_1_2_8_20_1","first-page":"504","article-title":"CTLA\u20104 polymorphism in myasthenia gravis","volume":"22","author":"Park J. 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