{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:43:40Z","timestamp":1788306220740,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/01186"],"award-info":[{"award-number":["PI15\/01186"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008055","name":"Fundaci\u00f3n Eugenio Rodr\u00edguez Pascual","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune diseases like celiac disease (CeD) and ulcerative colitis (UC) show a common genetic background defined by the existence of shared susceptibility loci. We aimed to go deeper into this common genetic background through performing a cross\u2010disease study based on gene expression. We measured the expression of 21 genes located in 13 CeD\u2010UC susceptibility regions, and 10 genes in five CeD risk regions. Determinations were carried out in colon\/rectum samples from 13 UC patients (inflamed and uninflamed tissue) and four colon samples from controls. Duodenal samples from 19 CeD patients and 12 controls were used for comparisons. Differences were analyzed using the Bayesian method. The shared chromosomal regions containing <jats:italic>TNFAIP3<\/jats:italic>, <jats:italic>PTPN2<\/jats:italic>, <jats:italic>ICOSLG, C1orf106<\/jats:italic>, and <jats:italic>IL21<\/jats:italic> showed similar results in both diseases. <jats:italic>FASLG<\/jats:italic>, <jats:italic>PLEK<\/jats:italic>, <jats:italic>CCR4<\/jats:italic>, and <jats:italic>TAGAP<\/jats:italic>, all located in CeD risk loci, were up\u2010regulated in both CeD and UC patients. Finally, <jats:italic>ZFP36L1<\/jats:italic>, <jats:italic>ZMIZ1<\/jats:italic>, <jats:italic>PUS10<\/jats:italic>, <jats:italic>UBE2L3<\/jats:italic>, and <jats:italic>BACH2<\/jats:italic> showed opposite results in CeD and UC. A high complexity underlies autoimmune common susceptibility loci, as the expression pattern of the studied genes does not always correlate with the one expected attending to the apparent genetic background. Differentially expressed genes such as <jats:italic>ZFP36L1<\/jats:italic>, <jats:italic>ZMIZ1<\/jats:italic>, <jats:italic>PUS10<\/jats:italic>, and <jats:italic>BACH2<\/jats:italic> deserve further research in autoimmune diseases.<\/jats:p>","DOI":"10.1111\/ahg.12293","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T05:50:43Z","timestamp":1541569843000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Expression patterns common and unique to ulcerative colitis and celiac disease"],"prefix":"10.1111","volume":"83","author":[{"given":"Luz Mar\u00eda","family":"Medrano","sequence":"first","affiliation":[{"name":"Servicio de Inmunolog\u00eda Cl\u00ednica Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid 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