{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:31:25Z","timestamp":1778045485792,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004847","name":"Zahedan University of Medical Sciences","doi-asserted-by":"publisher","award":["8373"],"award-info":[{"award-number":["8373"]}],"id":[{"id":"10.13039\/501100004847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several lines of evidence support an association between tropomyosin 1 (TPM1) and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL\/P). The present study aimed to investigate the association between <jats:italic>TPM1<\/jats:italic> polymorphisms and the risk of NSCL\/P in an Iranian population. This case\u2010control was done on 105 NSCL\/P patients and 110 unrelated healthy controls. <jats:italic>TPM1<\/jats:italic> rs11071720, rs3803499, rs12148828, and rs1972041 polymorphisms were genotyped by the polymerase chain reaction\u2010restriction fragment length polymorphism method. The finding showed that rs11071720 polymorphism significantly increased the risk of NSCL\/P in homozygous codominant (odds ratio [OR]\u00a0=\u00a02.54, 95% confidence interval [CI]\u00a0=\u00a01.14\u20135.69, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.023, TT vs. CC), recessive (OR\u00a0=\u00a02.33, 95% CI\u00a0=\u00a01.06\u20135.18, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021, TT vs. CT + CC), and allele (OR\u00a0=\u00a01.53, 95% CI\u00a0=\u00a01.02\u20132.30, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.030, T vs. C). The rs12148828 polymorphism was associated with protection against NSCL\/P in codominant (OR\u00a0=\u00a00.27, 95% CI\u00a0=\u00a00.15\u20130.48, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, TC vs. TT) and allele (OR\u00a0=\u00a00.38, 95% CI\u00a0=\u00a00.22\u20130.64, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, C vs. T). Regarding rs3803499, the findings proposed that this polymorphism significantly increased the risk of NSCL\/P in codominant (OR\u00a0=\u00a03.86, 95% CI\u00a0=\u00a01.19\u201312.56, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.025, CC vs. TT) and recessive (OR\u00a0=\u00a03.74, 95% CI\u00a0=\u00a01.09\u201314.15, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018, CC vs. CT + TT). No significant association was practical between rs1972041 polymorphism and NSCL\/P. In conclusion, the findings proposed that TPM1 polymorphisms may contribute to the etiology of NSCL\/P in a sample of the Iranian population.<\/jats:p>","DOI":"10.1111\/ahg.12310","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T01:20:58Z","timestamp":1553044858000},"page":"256-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of single nucleotide polymorphisms in TPM1 rs11071720, rs3803499, rs12148828, and rs1972041 with the risk of nonsyndromic cleft lip with or without cleft palate in a sample of the Iranian population, a preliminary report"],"prefix":"10.1111","volume":"83","author":[{"given":"Houshang","family":"Rafighdoost","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Tabatabaei","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Bahari","sequence":"additional","affiliation":[{"name":"Children and Adolescents Health Research Center Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-7101","authenticated-orcid":false,"given":"Mohammad","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Genetics of Non\u2010communicable Disease Research Center Zahedan University of Medical Sciences  Zahedan Iran"},{"name":"Department of Clinical Biochemistry, School of Medicine Zahedan University of Medical Sciences  Zahedan 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