{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:14:14Z","timestamp":1767651254329,"version":"3.40.5"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tuberculosis (TB) is a global issue as one\u2010third of the population worldwide is considered to be infected. TB has become a critical public health problem as a result of increasing drug resistance, which poses a challenge to current control strategies. Similar to environmental factors, genetic makeup of the host equally contributes to disease onset. We performed genotypic analysis to examine the relationship between <jats:italic>IFNG<\/jats:italic> and TB onset and drug resistance in a Pakistani population comprising 689 subjects. Notable differences were observed in the <jats:italic>IFNG<\/jats:italic> polymorphism (+874T\/A) between the case and control groups. The frequency of the wild\u2010type genotype (TT) in the controls (43.2%) was significantly higher than in the cases (25.3%) (odds ratio [OR] =\u00a00.77, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), while the mutant genotype frequency (AA) (38.57%) in the cases was significantly higher than in the controls (22.6%) (OR\u00a0=\u00a01.46, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). The heterozygous genotype frequency (TA) did not significantly differ between the control and case groups. Compared with the controls, the variant allele (A) was approximately twice as frequent in the cases. Females and older people have a higher chance of disease development. Finally, the <jats:italic>IFNG<\/jats:italic> (+874T\/A) polymorphism was not associated with drug sensitivity or resistance. However, a genotypic polymorphism of <jats:italic>IFNG<\/jats:italic> (+874T\/A) was significantly associated with susceptibility to TB, and the T allele conferred protection against TB. Additional studies involving larger cohorts are needed to further explore this relationship between genetics and disease vulnerability.<\/jats:p>","DOI":"10.1111\/ahg.12325","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T07:34:48Z","timestamp":1557387288000},"page":"426-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of single\u2010nucleotide polymorphisms in the <i>IFNG<\/i> towards susceptibility to tuberculosis in a Pakistani population"],"prefix":"10.1111","volume":"83","author":[{"given":"AsmaGul","family":"Naz","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ali","sequence":"additional","affiliation":[{"name":"Government College University  Faisalabad 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