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In our previous study, we observed a relationship between <jats:italic>NLRP13<\/jats:italic>, which is one of the members of the inflammasome complex and has a pyrin domain in its structure, and the <jats:italic>MEFV<\/jats:italic> gene using the STRING database. In this study, we examined <jats:italic>NLRP13<\/jats:italic> expression and methylation status in 40 patients with FMF attack and 20 healthy individuals. We then investigated the global DNA methylation status of patients with FMF in the attack period and control groups. We further examined the relationship between the clinical manifestation and global methylation as well as <jats:italic>NLRP13<\/jats:italic> gene expression of patients with FMF and healthy individuals. As a result, we showed that hypomethylation in patients with FMF leads to different clinical outcomes in terms of disease severity. In addition, the data indicated that <jats:italic>NLRP13<\/jats:italic> inflammasome is epigenetically controlled in patients with FMF and the presence of amyloidosis may affect the hypermethylation of this gene. Moreover, <jats:italic>NLRP13<\/jats:italic> was silenced because of the hypermethylation of the promoter. The increase of methylation level at the promoter region participated in the inactivation of <jats:italic>NLRP13<\/jats:italic>. In the current study, we not only found a new gene that plays a role in the pathogenesis of FMF disease, but also new evidence for the epigenetic regulation of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ahg.12493","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T08:03:57Z","timestamp":1672387437000},"page":"115-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["NLRP13 inflammasome complex is hypermethylated in familial Mediterranean fever and global methylation correlates with the disease severity"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-194X","authenticated-orcid":false,"given":"Feyzanur Yildirimtepe","family":"Caldiran","sequence":"first","affiliation":[{"name":"Faculty of Science and Art, Department of Molecular Biology and Genetics Tokat Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koksal","family":"Deveci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biochemistry Tokat Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Cacan","sequence":"additional","affiliation":[{"name":"Faculty of Science and Art, Department of Molecular Biology and Genetics Tokat Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"issue":"7","key":"e_1_2_10_2_1","first-page":"S90","article-title":"Alteration of the microRNA expression profile in familial Mediterranean fever patients","volume":"35","author":"Akkaya\u2010Ulum Y. 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