{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:13:38Z","timestamp":1781712818285,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2019H269"],"award-info":[{"award-number":["WJ2019H269"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Currently, several genetic variants in <jats:italic>ER\u03b1<\/jats:italic> gene (rs2234693 and rs9340799), <jats:italic>ER\u03b2<\/jats:italic> gene (rs1256049 and rs4986938), <jats:italic>KISS1<\/jats:italic> gene (rs4889, rs1132506 and rs5780218), <jats:italic>LIN28B<\/jats:italic> gene (rs314263, rs314276 and rs314280), and <jats:italic>MKRN3<\/jats:italic> gene (rs2239669) have been repeatedly explored for their contribution to precocious puberty (PP) susceptibility. However, the results remain conflicting rather than conclusive. We here performed a meta\u2010analysis to identify the real susceptibility genetic variants for PP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After screening by inclusion criteria, 20 related studies were finally included in this meta\u2010analysis. The odds ratios and 95% confidence intervals were calculated to assess the strength of association. Sensitive analysis, publication bias, and trial sequential analysis (TSA) were performed to evaluate the stability and reliability of results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rs2234693, rs9340799, and rs1256049 were significantly associated with PP susceptibility (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0084). Stratified analysis according to ethnicity showed that rs2234693 and rs9340799 were significantly associated with PP susceptibility in Asian and Chinese populations. Stratified analysis according to PP subtype showed that rs2234693 and rs9340799 were significantly associated with idiopathic central PP susceptibility in Asian and Chinese populations (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0084). The results of publication bias, sensitivity analysis, and TSA provided solid evidence for the association between these three variants and PP susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rs2234693 and rs9340799 in <jats:italic>ER\u03b1<\/jats:italic> gene and rs1256049 in <jats:italic>ER\u03b2<\/jats:italic> gene may serve as susceptive factors for PP development. The present finding should be confirmed in replication studies and reinforced in functional studies, which will ultimately improve the feasibility of the application of these three PP\u2010susceptible loci in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ahg.12525","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T07:14:37Z","timestamp":1699341277000},"page":"138-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A comprehensive meta\u2010analysis to identify susceptibility genetic variants for precocious puberty"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-9557","authenticated-orcid":false,"given":"Xiuli","family":"Gu","sequence":"first","affiliation":[{"name":"Wuhan Huake Reproductive Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weining","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences Wuhan University of Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Wuhan Huake Reproductive Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of reproductive health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Wuhan Huake Reproductive Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302160"},{"key":"e_1_2_9_3_1","volume-title":"The study on the association of single nucleotide polymorphisms and environmental factors for girls with idiopathic central precocious puberty","author":"Cai C. 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