{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:41:14Z","timestamp":1774953674745,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Irritable bowel syndrome (IBS) belongs to chronic functional gastrointestinal diseases featured by abdominal pain and changes in bowel habits. This study aimed to investigate the clinical significance of serum miR\u2010148 expression in different subtypes of IBS. We enrolled 86 IBS patients and 55 healthy controls. miR\u2010148 expression levels were assessed in IBS patients classified into IBS\u2010constipation (IBS\u2010C), IBS\u2010diarrhea (IBS\u2010D), and IBS\u2010mixed stool pattern (IBS\u2010M) subtypes. Receiver\u2010operating characteristic (ROC) curves were employed to evaluate the diagnostic potential of miR\u2010148 in distinguishing among IBS subtypes. Additionally, we analyzed the correlation between miR\u2010148 expression and clinical characteristics, including IBS symptom severity. miR\u2010148 expression was highest in IBS\u2010D (diarrhea) group, followed by IBS\u2010M and IBS\u2010C. With the exception of the IBS\u2010C group, miR\u2010148 expression was elevated in IBS patients compared to controls. ROC curve analysis demonstrated that serum miR\u2010148 exhibited higher diagnostic accuracy for discriminating IBS\u2010C and IBS\u2010D than IBS\u2010M. Correlation analysis revealed a positive relationship between serum miR\u2010148 relative expression and IBS symptom severity system scores. Univariate logistic analysis indicated a positive association between miR\u2010148 expression and IBS\u2010D and a negative correlation with IBS\u2010C. miR\u2010148 expression exhibits differential patterns among IBS subtypes and holds a potential to distinguish IBS\u2010C and IBS\u2010D. Furthermore, miR\u2010148 expression correlates with the severity of IBS symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ahg.12543","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T05:59:21Z","timestamp":1704088761000},"page":"247-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the clinical significance of miR\u2010148 expression variations in distinct subtypes of irritable bowel syndrome"],"prefix":"10.1111","volume":"88","author":[{"given":"Qun","family":"Ji","sequence":"first","affiliation":[{"name":"Department of General Practice Inner Mongolia Baogang Hospital  Baotou Inner Mongolia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengxia","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hospital Infection Management Inner Mongolia Baogang Hospital  Baotou Inner Mongolia 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