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Despite the significant progress in identifying novel biomarkers and understanding the prodromal pathology and symptomatology, AD remains a significant unmet clinical need. Lecanemab and aducanumab, the only Food and Drug Administration approved drugs to exhibit some disease\u2010modifying clinical efficacy, target A\u03b2 amyloid, underscoring the importance of this protein in disease aetiology. Nevertheless, in the absence of a definitive cure, the utilisation of preclinical models remains imperative for the identification of novel therapeutic targets and the evaluation of potential therapeutic agents.\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    is a model system that can be used as a research tool to investigate neurodegeneration and therapeutic interventions. The short lifespan, low price and ease of husbandry\/rearing make\n                    <jats:italic>Drosophila<\/jats:italic>\n                    an advantageous model organism from a practical perspective. However, it is the highly conserved genome and similarity of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    and human neurobiology which make flies a powerful tool to investigate neurodegenerative mechanisms. In addition, the ease of transgenic modifications allows for early proof of principle studies for future therapeutic approaches in neurodegenerative research. This mini review will specifically focus on utilising\n                    <jats:italic>Drosophila<\/jats:italic>\n                    as an in vivo model of amyloid toxicity in AD.\n                  <\/jats:p>","DOI":"10.1111\/ahg.12554","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T07:16:55Z","timestamp":1711091815000},"page":"349-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Using\n                    <i>Drosophila<\/i>\n                    amyloid toxicity models to study Alzheimer's disease"],"prefix":"10.1111","volume":"88","author":[{"given":"Elli","family":"Tsintzas","sequence":"first","affiliation":[{"name":"Department of Genetics, Evolution and Environment Institute of Healthy Ageing, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-0411","authenticated-orcid":false,"given":"Teresa","family":"Niccoli","sequence":"additional","affiliation":[{"name":"Department of Genetics, Evolution and Environment Institute of Healthy Ageing, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12068"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00215"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15233"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2016.07.009"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100689","article-title":"A protocol to detect neurodegeneration in Drosophila melanogaster whole\u2010brain mounts using advanced microscopy","volume":"2","author":"Behnke J. 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