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Additionally, nonsyndromic hearing loss is predominantly inherited in an autosomal recessive manner. We used Sanger sequencing to analyze <jats:italic>GJB2<\/jats:italic> in 17 deaf children from 13 unrelated Ivory Coast families. One family had two children born with severe congenital deafness and exhibited pathogenic compound heterozygous variants. These variants included a nonsense substitution (c.132G\u00a0&gt;\u00a0A or p.Trp44Ter) and a newly discovered duplication of 7 base pairs (c.205_211dupTTCCCCA or p.Ser72ProfsTer32). Segregation testing confirmed these variants, marking the first identification of <jats:italic>GJB2<\/jats:italic> in an Ivorian family with congenital hearing loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ahg.12574","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T05:33:06Z","timestamp":1722576786000},"page":"135-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First report of an Ivorian family with nonsyndromic hearing loss caused by <i>GJB2<\/i> compound heterozygous variants"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7827-9027","authenticated-orcid":false,"given":"Madoussou","family":"Toure","sequence":"first","affiliation":[{"name":"Genomics and Human Genetics Laboratory Institut Pasteur du Maroc  Casablanca Morocco"},{"name":"Ben M'Sik Faculty of science Hassan II University of Casablanca  Casablanca 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