{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:00:35Z","timestamp":1781780435883,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"2-3","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n The common genetic underpinnings of psoriasis and pulmonary comorbidities have yet to be explored.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n In this cross\u2010sectional study, we investigated the single\u2010nucleotide polymorphisms (SNPs) associated with psoriasis and their relationship with pulmonary function using data from the UK Biobank (UKBB) and the Vanderbilt University Medical Center Biobank (BioVU).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Out of the 63 psoriasis\u2010associated SNPs identified in previous genome\u2010wide association studies within the European population, we successfully identified 53 SNPs, including proxy SNPs in UKBB database. Following adjustments using age and sex, 31 SNPs displayed statistically significant associations with psoriasis. Among these, 16 SNPs exhibited significant associations with forced expiratory volume in 1\u00a0s (FEV\n 1<\/jats:sub>\n ), 14 with forced vital capacity (FVC), and 5 with the FEV\n 1<\/jats:sub>\n \/FVC ratio in the UKBB. In the validation analysis using the BioVU database, 27 of the 31 psoriasis\u2010associated SNPs were available for examination. Notably, the minor allele of SNP rs8016947 was confirmed to be significant, indicating a reduced risk for psoriasis and improved FEV\n 1<\/jats:sub>\n . Similarly, the minor alleles of SNPs rs17716942 and rs8016947 were associated with a reduced risk of psoriasis and enhanced FVC. However, none of the 5 SNPs significantly associated with the FEV\n 1<\/jats:sub>\n \/FVC ratio in the UKBB displayed significance in the BioVU dataset.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study has unveiled genetic variants that bridge the realms of psoriasis and lung function. The genes associated with these variants, including\n IFIH1<\/jats:italic>\n , Grancalcin gene (\n GCA<\/jats:italic>\n ), and NFKB inhibitor alpha gene (\n NFKBIA<\/jats:italic>\n ), regulate innate immune responses, which suggests that immunodysregulation, a central element in psoriasis pathogenesis, may also impact lung function, alluding to a \u201cskin\u2013lung axis.\u201d\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ahg.12587","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T08:52:58Z","timestamp":1735030378000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identifying a Genetic Link Between Lung Function and Psoriasis"],"prefix":"10.1111","volume":"89","author":[{"given":"Kazuya","family":"Tanimura","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Department of Respiratory Medicine Nara Medical University Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda C.","family":"Aldrich","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Jaworski","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchuan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Genetics Human Genetic Institute of New Jersey, Rutgers, the State University of New Jersey Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Okawa","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divay","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed M.","family":"Nouraie","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-4607","authenticated-orcid":false,"given":"Toru","family":"Nyunoya","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Medical Specialty Service Line Veterans Affairs Pittsburgh Healthcare System Pittsburgh Pennsylvania 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