{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:55:24Z","timestamp":1781358924473,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Human Genetics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The bone\u2013brain axis has emerged as a critical framework linking skeletal metabolism to neurodegeneration. Within this axis, bone marrow adipose tissue (BMAT) represents a unique fat depot with distinct endocrine and hematopoietic functions, yet its contribution to Alzheimer's disease (AD) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a two\u2010sample Mendelian randomization (MR) analysis using genome\u2010wide association study (GWAS) summary statistics to assess the causal effects of six fat depots\u2014abdominal\u00a0subcutaneous, visceral, spinal, femoral head, total hip, and femoral diaphysis fat\u2014on AD risk. Mediation analysis was further performed to evaluate whether femoral neck bone mineral density (BMD) mediates these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the six depots, only total hip BMAT showed a significant causal association with AD risk (OR = 1.28, 95% CI: 1.09\u20131.51,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). Total hip BMAT was inversely related to femoral neck BMD (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u20130.43, 95% CI: \u20130.61 to \u20130.24,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), whereas no causal relationship was detected between BMD and AD (OR = 1.01, 95% CI: 0.89\u20131.15,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.849), excluding bone loss as a mediator.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first genetic evidence that excessive hip BMAT increases the risk of AD, supporting the bone\u2013brain axis hypothesis. These findings highlight BMAT as a novel target for understanding and potentially preventing AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ahg.70041","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:06:52Z","timestamp":1779170812000},"page":"249-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis"],"prefix":"10.1111","volume":"90","author":[{"given":"Wei","family":"Shi","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Sports Injury and Precision Therapy Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Sports Injury and Precision Therapy Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan Central Hospital  Xiaogan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Sports Injury and Precision Therapy Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Xu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Sports Injury and Precision Therapy Wuhan Fourth Hospital  Wuhan 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