{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:00:39Z","timestamp":1758862839755,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01-DA026831"],"award-info":[{"award-number":["R01-DA026831"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Psychomotor restlessness and agitation (PMA) is a putatively important, yet understudied, psychopathologic correlate of smoking. The scant smoking research on PMA previously conducted has been narrow in scope and conducted among psychiatric patients. To examine the generalizability and relevance of PMA to smoking, this cross\u2010sectional study investigated associations between PMA and a variety of smoking processes in a community sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants in this study were non\u2010treatment\u2010seeking smokers (<jats:italic>N<\/jats:italic>\u2009=\u2009254, \u226510\u2009cig\/day, <jats:italic>M<\/jats:italic> age\u2009=\u200944 years) from the community without an active mood disorder. At baseline, they completed a PMA symptom checklist, a composite depressive symptom index, and a battery of smoking questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Linear regression models adjusting for depressive symptoms and demographics indicated that PMA level was positively associated with severity of nicotine withdrawal symptoms during prior quit attempts (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.18, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), anticipated likelihood of withdrawal in a future quit attempt (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.19, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), motivation to smoke for negative reinforcement (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.14, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), and smoking expectancies for negative reinforcement (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.17, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), negative consequences (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.22, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), and positive reinforcement (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.14, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). PMA was not significantly associated with smoking chronicity, frequency, or dependence severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Scientific Significance<\/jats:title><jats:p>Smokers with elevated PMA appear to experience greater smoking\u2010induced affect modulation and nicotine withdrawal than the average smoker, regardless of other depressive symptoms. Given that PMA differentiates a qualitatively unique profile of smoking characteristics, PMA warrants consideration in tobacco addiction research and practice. 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