{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:18:29Z","timestamp":1764332309569,"version":"3.41.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":130,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Detroit Wayne Mental Health Authority","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Joe Young, Sr.\/Helene Lycaki Funds (State of Michigan)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Addict"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1111\/ajad.12187","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T20:54:56Z","timestamp":1429908896000},"page":"329-335","source":"Crossref","is-referenced-by-count":31,"title":["Functional<i>mu<\/i>opioid receptor polymorphism (<i>OPRM1 A<sup>118<\/sup>G<\/i>) associated with heroin use outcomes in Caucasian males: A pilot study"],"prefix":"10.1111","volume":"24","author":[{"given":"Eric A.","family":"Woodcock","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences; Wayne State University; Detroit Michigan"},{"name":"Translational Neuroscience Program; Wayne State University; Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie H.","family":"Lundahl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences; Wayne State University; Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit","family":"Burmeister","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry; Human Genetics and Computational Medicine and Bioinformatics; Molecular and Behavioral Neuroscience Institute; University of Michigan; Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark K.","family":"Greenwald","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences; Wayne State University; Detroit Michigan"},{"name":"Translational Neuroscience Program; Wayne State University; Detroit Michigan"},{"name":"Department of Pharmacy Practice; Wayne State University; Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"10.1111\/ajad.12187-BIB0001|ajad12187-cit-0001","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0026-895X(25)09932-8","article-title":"Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors","volume":"45","author":"Raynor","year":"1994","journal-title":"Mol Pharmacol."},{"key":"10.1111\/ajad.12187-BIB0002|ajad12187-cit-0002","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.resp.2008.02.004","article-title":"Opioidergic and dopaminergic modulation of respiration","volume":"164","author":"Lalley","year":"2008","journal-title":"Respir Physiol Neurobiol."},{"key":"10.1111\/ajad.12187-BIB0003|ajad12187-cit-0003","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/ALN.0b013e318224cc1f","article-title":"Activation of opioid \u03bc-receptors in the commissural subdivision of the nucleus tractus solitarius abolishes the ventilatory response to hypoxia in anesthetized rats","volume":"115","author":"Zhang","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1111\/ajad.12187-BIB0004|ajad12187-cit-0004","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/sj.mp.4000331","article-title":"Mu opioid receptor gene variants: Lack of association with alcohol dependence","volume":"2","author":"Bergen","year":"1997","journal-title":"Mol Psychiatry."},{"key":"10.1111\/ajad.12187-BIB0005|ajad12187-cit-0005","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1073\/pnas.95.16.9608","article-title":"Single-nucleotide polymorphism in the human mu opioid receptor gene alters \u03b2-endorphin binding and activity: Possible implications for opiate addiction","volume":"95","author":"Bond","year":"1998","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1111\/ajad.12187-BIB0006|ajad12187-cit-0006","doi-asserted-by":"crossref","first-page":"32618","DOI":"10.1074\/jbc.M504942200","article-title":"Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G","volume":"280","author":"Zhang","year":"2005","journal-title":"J Biol Chem."},{"key":"10.1111\/ajad.12187-BIB0007|ajad12187-cit-0007","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1093\/hmg\/dds314","article-title":"Genetic-epigenetic interaction modulates \u03bc-opioid receptor regulation","volume":"21","author":"Oertel","year":"2012","journal-title":"Hum Mol Genet."},{"key":"10.1111\/ajad.12187-BIB0008|ajad12187-cit-0008","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1369-1600.2012.00484.x","article-title":"Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPgammaS binding in mice with OPRM1 A112G","volume":"19","author":"Wang","year":"2012a","journal-title":"Addict Biol."},{"key":"10.1111\/ajad.12187-BIB0009|ajad12187-cit-0009","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(76)91009-X","article-title":"Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray","volume":"114","author":"Yaksh","year":"1976","journal-title":"Brain Res."},{"key":"10.1111\/ajad.12187-BIB0010|ajad12187-cit-0010","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1098\/rstb.1999.0483","article-title":"Pain and functional imaging","volume":"354","author":"Ingvar","year":"1999","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"10.1111\/ajad.12187-BIB0011|ajad12187-cit-0011","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0987-7053(00)00227-6","article-title":"Functional imaging of brain responses to pain. A review and meta-analysis","volume":"30","author":"Peyron","year":"2000","journal-title":"Clin Neurophysiol."},{"key":"10.1111\/ajad.12187-BIB0012|ajad12187-cit-0012","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1073\/pnas.0901800106","article-title":"Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior","volume":"106","author":"Mague","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1111\/ajad.12187-BIB0013|ajad12187-cit-0013","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00000542-200608000-00016","article-title":"Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy","volume":"105","author":"Chou","year":"2006a","journal-title":"Anesthesiology."},{"key":"10.1111\/ajad.12187-BIB0014|ajad12187-cit-0014","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1399-6576.2006.01058.x","article-title":"Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty","volume":"50","author":"Chou","year":"2006b","journal-title":"Acta Anaesthesiol Scand."},{"key":"10.1111\/ajad.12187-BIB0015|ajad12187-cit-0015","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/ALN.0b013e318182af21","article-title":"A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia","volume":"109","author":"Sia","year":"2008","journal-title":"Anesthesiology."},{"key":"10.1111\/ajad.12187-BIB0016|ajad12187-cit-0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-8069-5-32","article-title":"Ethnicity and OPRM1 variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain","volume":"5","author":"Tan","year":"2009","journal-title":"Mol Pain."},{"key":"10.1111\/ajad.12187-BIB0017|ajad12187-cit-0017","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/BJ20111050","article-title":"A common single nucleotide polymorphism A118G of the mu opioid receptor alters its N-glycosylation and protein stability","volume":"441","author":"Huang","year":"2012","journal-title":"Biochem J."},{"key":"10.1111\/ajad.12187-BIB0018|ajad12187-cit-0018","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1471-4159.2004.02340.x","article-title":"Effect of the A118G polymorphism on binding affinity, potency, and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor","volume":"89","author":"Beyer","year":"2004","journal-title":"J Neurochem."},{"key":"10.1111\/ajad.12187-BIB0019|ajad12187-cit-0019","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1471-4159.2007.04738.x","article-title":"The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor","volume":"103","author":"Kroslak","year":"2007","journal-title":"J Neurochem."},{"key":"10.1111\/ajad.12187-BIB0020|ajad12187-cit-0020","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1073\/pnas.1018699108","article-title":"Human mu opioid receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers","volume":"108","author":"Ray","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1111\/ajad.12187-BIB0021|ajad12187-cit-0021","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S146114571200017X","article-title":"Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: Preliminary findings in human subjects","volume":"16","author":"Weerts","year":"2013","journal-title":"Int J Neuropsychopharmacol."},{"key":"10.1111\/ajad.12187-BIB0022|ajad12187-cit-0022","first-page":"9","article-title":"Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis","volume":"2","author":"Coller","year":"2009","journal-title":"Pharmacogenomics Pers Med."},{"key":"10.1111\/ajad.12187-BIB0023|ajad12187-cit-0023","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.drugalcdep.2005.11.024","article-title":"Association of an Asn40Asp (A118G) polymorphism in the \u03bc-opioid receptor gene with substance dependence: A meta analysis","volume":"83","author":"Arias","year":"2006","journal-title":"Drug Alcohol Depend."},{"key":"10.1111\/ajad.12187-BIB0024|ajad12187-cit-0024","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2217\/pgs.13.57","article-title":"OPRM1 rs1799971 polymorphism and opioid dependence: Evidence from a meta-analysis","volume":"7","author":"Haerian","year":"2013","journal-title":"Pharmacogenomics."},{"key":"10.1111\/ajad.12187-BIB0025|ajad12187-cit-0025","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/nn1583","article-title":"Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction","volume":"8","author":"Kreek","year":"2005","journal-title":"Nature Neuroscience."},{"key":"10.1111\/ajad.12187-BIB0026|ajad12187-cit-0026","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.pharmtox.010909.105826","article-title":"Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment","volume":"50","author":"Khokhar","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"10.1111\/ajad.12187-BIB0027|ajad12187-cit-0027","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.drugalcdep.2010.12.026","article-title":"No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample","volume":"117","author":"Nikolov","year":"2011","journal-title":"Drug Alcohol Depend."},{"key":"10.1111\/ajad.12187-BIB0028|ajad12187-cit-0028","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/humu.9026","article-title":"Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin","volume":"19","author":"Shi","year":"2002","journal-title":"Human Mutat."},{"key":"10.1111\/ajad.12187-BIB0029|ajad12187-cit-0029","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s13181-012-0286-3","article-title":"Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population","volume":"2","author":"Manini","year":"2013","journal-title":"J Med Toxicol."},{"key":"10.1111\/ajad.12187-BIB0030|ajad12187-cit-0030","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2011.12.033","article-title":"Reduced expression of the mu opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G","volume":"205","author":"Wang","year":"2012b","journal-title":"Neuroscience."},{"key":"10.1111\/ajad.12187-BIB0031|ajad12187-cit-0031","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.drugalcdep.2006.03.007","article-title":"Behavioral economic analysis of opioid consumption in heroin-dependent individuals: Effects of unit price and pre-session drug supply","volume":"85","author":"Greenwald","year":"2006","journal-title":"Drug Alcohol Depend."},{"key":"10.1111\/ajad.12187-BIB0032|ajad12187-cit-0032","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.drugalcdep.2009.04.006","article-title":"Behavioral economic analysis of opioid consumption in heroin-dependent individuals: Effects of alternative reinforcer magnitude and post-session drug supply","volume":"104","author":"Greenwald","year":"2009","journal-title":"Drug Alcohol Depend."},{"key":"10.1111\/ajad.12187-BIB0033|ajad12187-cit-0033","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.drugalcdep.2010.03.020","article-title":"Effects of experimental unemployment, employment and punishment analogs on opioid seeking and consumption in heroin-dependent volunteers","volume":"111","author":"Greenwald","year":"2010","journal-title":"Drug Alcohol Depend."},{"key":"10.1111\/ajad.12187-BIB0034|ajad12187-cit-0034","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00213-012-2868-9","article-title":"Yohimbine increases opioid-seeking behavior in heroin-dependent, buprenorphine-maintained individuals","volume":"225","author":"Greenwald","year":"2013","journal-title":"Psychopharmacology."},{"key":"10.1111\/ajad.12187-BIB0035|ajad12187-cit-0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/bmj.2.5402.177","article-title":"Human experimentation. Code of ethics of the World Medical Association Declaration of Helsinki","volume":"2","author":"Rickham","year":"1964","journal-title":"Br Med J"},{"key":"10.1111\/ajad.12187-BIB0036|ajad12187-cit-0036","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/alcalc\/agn032","article-title":"Addictions biology: Haplotype-based analysis for 130 candidate genes on a single array","volume":"43","author":"Hodgkinson","year":"2008","journal-title":"Alcohol Alcohol."},{"key":"10.1111\/ajad.12187-BIB0037|ajad12187-cit-0037","first-page":"56","volume-title":"Structural equation modeling: Concepts, issues, and applications","author":"West","year":"1995"},{"key":"10.1111\/ajad.12187-BIB0038|ajad12187-cit-0038","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0376-8716(00)00204-0","article-title":"Differences in severity of heroin dependence by route of administration: The importance of length of heroin use","volume":"63","author":"Barrio","year":"2001","journal-title":"Drug Alcohol Depend."},{"key":"10.1111\/ajad.12187-BIB0039|ajad12187-cit-0039","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1111\/j.1360-0443.1992.tb02660.x","article-title":"Severity of dependence and route of administration of heroin, cocaine, and amphetamines","volume":"87","author":"Gossop","year":"1992","journal-title":"Br J Addict."},{"key":"10.1111\/ajad.12187-BIB0040|ajad12187-cit-0040","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1046\/j.1360-0443.1999.94811919.x","article-title":"The influence of heroin dose and route of administration on the severity of the opiate withdrawal syndrome","volume":"94","author":"Smolka","year":"1999","journal-title":"Addiction."},{"key":"10.1111\/ajad.12187-BIB0041|ajad12187-cit-0041","first-page":"176","article-title":"Lapse and relapse following treatment of opiate dependence","volume":"103","author":"Smyth","year":"2010","journal-title":"Ir Med J."},{"key":"10.1111\/ajad.12187-BIB0042|ajad12187-cit-0042","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00213-006-0504-2","article-title":"Association of OPRM1 A118G variant with the relative reinforcing value of nicotine","volume":"188","author":"Ray","year":"2006","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1111\/ajad.12187-BIB0043|ajad12187-cit-0043","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/sj.tpj.6500432","article-title":"Association of the mu-opioid receptor gene with smoking cessation","volume":"7","author":"Munaf\u00f2","year":"2007","journal-title":"Pharmacogenomics J."},{"key":"10.1111\/ajad.12187-BIB0044|ajad12187-cit-0044","first-page":"680","article-title":"Gender differences in the genetic risk for alcohol dependence - The results of a pharmacogenetic study in Korean alcoholics","volume":"44","author":"Kim","year":"2009","journal-title":"Japanese Journal of Alcohol Studies & Drug Dependence"},{"key":"10.1111\/ajad.12187-BIB0045|ajad12187-cit-0045","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jpain.2004.11.008","article-title":"The A118G single nucleotide polymorphism of the \u03bc-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans","volume":"6","author":"Fillingim","year":"2005","journal-title":"J Pain."}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajad.12187","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ajad.12187\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T22:39:01Z","timestamp":1747953541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.12187"}},"subtitle":["Heroin Phenotypes by<i>OPRM1 A<sup>118<\/sup>G<\/i>"],"short-title":[],"issued":{"date-parts":[[2015,4,24]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,6]]}},"URL":"https:\/\/doi.org\/10.1111\/ajad.12187","relation":{},"ISSN":["1055-0496"],"issn-type":[{"type":"print","value":"1055-0496"}],"subject":[],"published":{"date-parts":[[2015,4,24]]}}}