{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:39:30Z","timestamp":1788910770844,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37 DA015969"],"award-info":[{"award-number":["R37 DA015969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Findings from uncontrolled studies suggest that the <jats:italic>COMT<\/jats:italic> Val108\/158Met polymorphism may affect response to cognitive behavioral therapy (CBT) in some populations. Using data from a randomized controlled trial evaluating computerized CBT (CBT4CBT), we evaluated treatment response by <jats:italic>COMT<\/jats:italic> genotype, with the a priori hypothesis that Val carriers would have improved response to computerized delivery of CBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>101 cocaine\u2010dependent individuals, of whom 81 contributed analyzable genetic samples, were randomized to standard methadone maintenance treatment plus CBT4CBT or standard treatment alone in an 8 week trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant genotype by time effect on frequency of cocaine use from baseline to the end of the 6 month follow\u2010up, suggesting greater reductions over time for Val carriers relative to individuals with the Met\/Met genotype. There was a significant treatment condition by genotype interactions for rates of participants attaining 21 or more days of continuous abstinence as well as self\u2010reported percent days of abstinence, suggesting less cocaine use among Val carriers when assigned to CBT compared to standard treatment. Exploration of possible mechanisms using measures of attentional biased also pointed to greater change over time in these measures among the Val carriers assigned to CBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These are the first data from a randomized controlled trial indicating significant interactions of <jats:italic>COMT<\/jats:italic> polymorphism and behavioral therapy condition on treatment outcome, where Val carriers appeared to respond particularly well to computerized CBT. These preliminary data point to a potential biomarker of response to CBT linked to its putative mechanism of action, enhanced cognitive control. (Am J Addict 2015;24:443 \u2013451)<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.12238","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T10:46:50Z","timestamp":1430477210000},"page":"443-451","source":"Crossref","is-referenced-by-count":9,"title":["Catehol\u2010o\u2010methyltransferase gene Val158met polymorphism as a potential predictor of response to computer\u2010assisted delivery of cognitive\u2010behavioral therapy among cocaine\u2010dependent individuals: Preliminary findings from a randomized controlled trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Kathleen M.","family":"Carroll","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine West Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryeh","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine West Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise E.","family":"DeVito","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine West Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami L.","family":"Frankforter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine West Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc N.","family":"Potenza","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine West Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sofuoglu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine West Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2009.70.516"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.67.4.563"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001816"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00548"},{"key":"e_1_2_8_6_1","article-title":"Cognitive behavioral therapy and neuroscience: Towards closer integration","volume":"19","author":"Joic\u2010 Begic N","year":"2010","journal-title":"Psychol Topics"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.1.34"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2007.05.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.4.457"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2005.07.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2010.05.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-006-9118-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022538713914"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950120061010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2345"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03076.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1176\/jnp.2009.21.2.114","article-title":"Does cognitive behavioral therapy change the brain? A systematic review of neuroimaging in anxiety disorders","volume":"21","author":"Porto PR","year":"2009","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291705005064"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.02.009"},{"key":"e_1_2_8_20_1","first-page":"4","article-title":"Beyond dopamine: Functional MRI predictors of responsiveness to cognitive behaviour therapy for psychosis","volume":"4","author":"Kumari V","year":"2010","journal-title":"Front Behav Neurosci"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013353613591"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.137.2.201"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111134598"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb04599.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.4.652"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.6.1110"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2009.03.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2005.04.012"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.11.012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-10-99"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079015"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.33"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.132"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.92"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.03.016"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01834.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08040528"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","DOI":"10.4324\/9780203962152","volume-title":"Hands On Help: Computer\u2010Aided Psychotherapy","author":"Marks IM","year":"2007"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07111835"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.09.015"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070987"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/FPC.0b013e328340bdf2","article-title":"Are genetic variants of COMT associated with addiction?","volume":"20","author":"Tammimaki AE","year":"2010","journal-title":"Pharmacogenet Genomics"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.126"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2013.09.012"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282f44daa"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.132.3.443"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsas.1994.s12.70"},{"key":"e_1_2_8_50_1","volume-title":"Structured Clinical Interview for DSM\u2010IV, Patient Edition","author":"First MB","year":"1995"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0030992"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2004.06.003"},{"key":"e_1_2_8_53_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1176\/jnp.16.4.456","article-title":"Prefrontal cortical dysfunction in abstinent cocaine abusers","volume":"16","author":"Bolla K","year":"2004","journal-title":"J Neuropsychiatr Clin Neurosci"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.01.012"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.68.1.64"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajad.12238","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.12238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:44:30Z","timestamp":1696376670000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.12238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/ajad.12238"],"URL":"https:\/\/doi.org\/10.1111\/ajad.12238","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}