{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T10:58:31Z","timestamp":1778410711648,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>While the risk of opioid overdose is widely accepted, the dangers of opioid withdrawal are far less clearly defined. The purpose of this publication is to provide evidence against the erroneous clinical dictum that opioid withdrawal is never life\u2010threatening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This case report (<jats:italic>N<\/jats:italic>\u2009=\u20091) illustrates an unfortunate, common scenario of a man abusing prescription opioids and heroin. His attempt at self\u2010detoxification with buprenorphine\u2013naloxone resulted in life\u2010threatening opioid withdrawal. A detailed account of each day of his withdrawal period was documented by patient and family report and review of all medical records. The patient was contacted three months after hospitalization to verify information and determine progress in treatment and abstinence from drugs and alcohol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>A review of the literature was completed on severe cases of precipitated and spontaneous opioid withdrawal followed by a discussion of the significance as it relates to this case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>Given the widespread use of prescription opioids and opioid maintenance treatment, physicians should be aware of the complications of acute opioid withdrawal and should be equipped to treat these complications. 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Causes of rhabdomyolysis [Internet]: UpToDate [updated September 19 2014; cited May 11 2015]. Available from:http:\/\/www.uptodate.com\/contents\/causes\u2010of\u2010rhabdomyolysis?source=search_result&search=rhabdomyolysis&selectedTitle=1%7 E150."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(00)00180-3"},{"key":"e_1_2_6_11_1","unstructured":"TriadafilopoulosG. Boerhaave syndrome: Effort rupture of the esophagus [Internet]: UpToDate; 2014 [updated December 19; cited April 22 2015]. 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