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This study assessed 23 variables that might help identify prolonged QTc during MMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EKGs concurrent with methadone serum levels were obtained from 69 veterans during a 5\u2010year study, encompassing 302.8 person\u2010years. Two cardiologists hand\u2010measured QT intervals, selecting each patient's longest QTc. QTc categories included: <jats:italic>normal<\/jats:italic> duration &lt;440\u2009ms; <jats:italic>borderline<\/jats:italic> duration of 440\u2013469\u2009ms; and <jats:italic>abnormal<\/jats:italic> duration \u2265470\u2009ms. QTc's were compared with seven methadone parameters and 16 bio\u2010psycho\u2010social variables using two QTc cut\u2010offs (440 and 470\u2009ms).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 69 patients, 19 had normal QTc's, 28 had borderline QTc's, and 22 had abnormal QTc's. Methadone dose\/weight was moderately correlated with QTc, and independently associated with longer QTc at both 440 and 470 cut\u2010offs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>Dose\/weight \u2265.49 is useful for screening EKGs for QTc's \u2265440 cut\u2010off. Dose\/weight \u2265.65 produces high\u2010yield abnormal QTc's \u2265470 cut\u2010off.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>Methadone dose\/weight provides moderately reliable thresholds for making routine screening decisions and urgent clinical decisions to obtain an EKG for prolonged QTc. (Am J Addict 2016;25:499\u2013507).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.12423","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T16:16:39Z","timestamp":1471882599000},"page":"499-507","source":"Crossref","is-referenced-by-count":11,"title":["Methadone maintenance dose\/weight ratio, long QTc, and EKG screening"],"prefix":"10.1111","volume":"25","author":[{"given":"Joseph","family":"Westermeyer","sequence":"first","affiliation":[{"name":"Mental Health Service Minneapolis VA Medical Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcuk","family":"Adabag","sequence":"additional","affiliation":[{"name":"Cardiology Service Minneapolis VA Medical Center Minneapolis Minnesota"},{"name":"Department of Medicine Health Sciences Center University of Minnesota Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhu","family":"Anand","sequence":"additional","affiliation":[{"name":"Cardiology Service Minneapolis VA Medical Center Minneapolis Minnesota"},{"name":"Department of Medicine Health Sciences Center University of Minnesota Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thuras","sequence":"additional","affiliation":[{"name":"Mental Health Service Minneapolis VA Medical Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gihyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Mental Health Service West Haven VA Medical Center West Haven Connecticut"},{"name":"Department of Psychiatry Yale University Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tegan","family":"Batres\u2010y\u2010Carr","sequence":"additional","affiliation":[{"name":"Mental Health Service Minneapolis VA Medical Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","volume-title":"Increases in Poisoning and Methadone\u2010Related Deaths: United States, 1999\u20132005. 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