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Multiple domains were assessed including sociodemographic factors; ecological factors (census\u2010defined neighborhood disadvantage, geocoded density of casinos within 30 miles of respondents\u2019 homes, and perceived gambling convenience); impulsivity; and alcohol abuse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After controlling for all variables in the study, neighborhood disadvantage has a significantly greater effect on overall gambling, frequent gambling, and problem gambling for Native Americans than for the rest of the U.S. population. In addition, the relationship between frequent gambling and heavier drinking is much stronger for blacks than for the rest of the U.S. population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>There is a lack of research on gambling involvement among minority groups in the U.S. Blacks and Native Americans are at a higher risk for problem gambling as compared with the rest of the population. Furthermore, social factors and alcohol abuse may show a stronger co\u2010occurrence with gambling involvement among minority groups than among whites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>This study is a large representative U.S. sample with sizeable numbers of Native Americans and blacks. Thus, prevalence rates and risk factors can be assessed for these important population subgroups. This will allow for targeted intervention programs for Native Americans and blacks with problem gambling and alcohol abuse. 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