{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:49:21Z","timestamp":1791985761922,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Rising concerns regarding diversion and misuse of mono\u2010buprenorphine for treatment of pregnant women with opioid use disorders have sparked interest in the use of buprenorphine\u2009+\u2009naloxone to reduce misuse and diversion rates. Examined the relationship of prenatal buprenorphine\u2009+\u2009naloxone exposure to neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective chart review of 26 mother infant dyads in comprehensive medication\u2010assisted treatment with buprenorphine\u2009+\u2009naloxone during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All neonatal birth outcome parameters were within normal ranges, albeit on the lower side of normal for gestational age and birth weight. Only 19% of neonates required morphine pharmacology for NAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of buprenorphine\u2009+\u2009naloxone shows relative safety in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>These findings can help better guide prescribing practices for pregnant patients at risk for misuse or diversion of buprenorphine. (Am J Addict 2018;27:92\u201396)<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.12687","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T07:46:46Z","timestamp":1519372006000},"page":"92-96","source":"Crossref","is-referenced-by-count":27,"title":["Treating women with opioid use disorder during pregnancy in Appalachia: Initial neonatal outcomes following buprenorphine\u2009+\u2009naloxone exposure"],"prefix":"10.1111","volume":"27","author":[{"given":"Linda","family":"Nguyen","sequence":"first","affiliation":[{"name":"Departments of Neurosciences and Pediatrics University of California, San Diego San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura R.","family":"Lander","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine and Psychiatry West Virginia University Morgantown West Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin E.","family":"O'Grady","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Maryland, College Park College Park Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-2975","authenticated-orcid":false,"given":"Patrick J.","family":"Marshalek","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine and Psychiatry West Virginia University Morgantown West Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Schmidt","sequence":"additional","affiliation":[{"name":"UNC Horizons and Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology School of Medicine Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audra K.","family":"Kelly","sequence":"additional","affiliation":[{"name":"School of Medicine West Virginia University Morgantown West Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendr\u00e9e E.","family":"Jones","sequence":"additional","affiliation":[{"name":"UNC Horizons and Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology School of Medicine Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318256496e"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization. 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