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Weighted analyses estimated the prevalence of the top 10 patterns of current alcohol, marijuana, and tobacco use and co\u2010use separately by young adults aged 18\u201324 (<jats:italic>n<\/jats:italic>\u2009=\u20099,112) and adults 25+ years (<jats:italic>n<\/jats:italic>\u2009=\u200923,208). Multivariable models examined associations of substance use and mental health problems to patterns of use, adjusting for demographics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across both age groups, alcohol\u2010only use was the most popular use pattern (20.7% for young adults and 32.2% older adults) however poly\u2010substance use patterns were more frequent than single use patterns. Cigarettes were the only tobacco product used exclusively; all other tobacco products were used with together, or with alcohol or marijuana. Only one young adult pattern emerged containing e\u2010cigarettes, and this pattern included co\u2010use with alcohol and cigarettes (1.3%). Mental health and substance use problems were most strongly correlated with dual and poly\u2010substance use patterns, regardless of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>Prevention and intervention campaigns should focus on multiple product use, as single substance use is uncommon. Alcohol is common in all patterns, suggesting it should also gain more focus in marijuana and tobacco prevention and intervention programs. 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