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The common variant rs324420 C\u2010&gt;A within the <jats:italic>FAAH<\/jats:italic> gene on chromosome 1 codes for a missense substitution (Pro129Thr), resulting in decreased FAAH activity and increased endocannabinoid potentiation. This FAAH variant has been linked to alterations in mood and stress reactivity, as well as being independently linked to increased risk for addiction. We hypothesized that cocaine use disordered (CUD) participants with the FAAH Pro129 Thr variant would exhibit a distinct profile of cocaine\u2010induced subjective effects in the laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 70 CUD participants received intravenous doses of saline (placebo, 0\u2009mg) and cocaine (20, 40\u2009mg) in a lab\u2010controlled setting and rated 10 subjective effect measures prior to and following saline and cocaine administration, using a Visual Analog Scale (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The variant allele was associated with increased cocaine\u2010induced subjective ratings for \u201cDrug Effect,\u201d \u201cHigh,\u201d and \u201cDepressed.\u201d The prevalence of the variant allele A and the AA genotypes were greater in our CUD group than in the general population (A allele: 47% vs. 34%; AA genotype: 30% vs. 13%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Finally, the reported amount and frequency of tobacco and cocaine use was higher in subjects with the AC\/AA allele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Scientific Significance<\/jats:title><jats:p>These results add to existing evidence that this variant of the <jats:italic>FAAH<\/jats:italic> genotype may be over\u2010represented among those who have CUD, and this over\u2010representation may result from greater subjective responses to cocaine administration. (Am J Addict 2018;27:567\u2013573)<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.12788","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T14:55:21Z","timestamp":1534949721000},"page":"567-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-1239","authenticated-orcid":false,"given":"Marguerite M.","family":"Patel","sequence":"first","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston Texas"},{"name":"Michael E. 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