{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:24:17Z","timestamp":1784751857694,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA017296"],"award-info":[{"award-number":["R01DA017296"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Topiramate has been studied in the treatment of substance use disorders and is often used off\u2010label in the treatment of other disorders with impaired impulse control. We sought to determine whether impulsiveness could predict topiramate treatment response in individuals with cocaine use disorder (CUD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a post\u2010hoc analysis of a 12\u2010week, double\u2010blind, randomized, placebo\u2010controlled trial of topiramate for CUD, we examined the relationship between response to treatment and participants\u2019 baseline score on the Barrett Impulsiveness Scale (BIS\u201011). During the original trial, topiramate was titrated up to 300\u2009mg\/day over 6 weeks and maintained for 6 weeks. All participants received weekly cognitive behavioral therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with total BIS\u201011 scores above the median had 11.2% more cocaine\u2010free days with topiramate versus placebo (Bonferroni corrected <jats:italic>p<\/jats:italic>\u2009=\u20090.047). Individuals with first\u2010order factor scores above the median in self\u2010control (Bonferroni corrected <jats:italic>p<\/jats:italic>\u2009=\u20090.020) and at or below the median in attention (Bonferroni corrected <jats:italic>p<\/jats:italic>\u2009=\u20090.022), and second\u2010order factor scores at or below the median in attentional (Bonferroni corrected <jats:italic>p<\/jats:italic>\u2009=\u20090.024) and motor impulsiveness (Bonferroni corrected <jats:italic>p<\/jats:italic>\u2009=\u20090.046) were all associated with a greater improvement with topiramate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusion<\/jats:title><jats:p>The results indicate an association between higher within\u2010group impulsiveness and response to topiramate for CUD. The subscore findings may suggest a complex interaction between effectiveness and known cognitive side effects. The finding that trait impulsiveness is associated with treatment response is a promising discovery that may help guide treatment for CUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>This analysis suggests a possible endophenotype based on impulsiveness that can predict treatment response to topiramate. (Am J Addict 2019;XX:1\u20136).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.12858","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T13:51:54Z","timestamp":1548078714000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impulsiveness as a predictor of topiramate response for cocaine use disorder"],"prefix":"10.1111","volume":"28","author":[{"given":"Derek","family":"Blevins","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University\/New York State Psychiatric Institute New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Virginia Charlottesville 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