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Individuals who experienced a recent sexual assault are at risk for increased substance use, yet limited interventions target PO misuse after sexual assault. The current study examined the efficacy of video interventions on PO misuse after sexual assault.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescent girls and women (<jats:italic>n\u2009=\u2009<\/jats:italic>154) were recruited in the context of a sexual assault medical forensic exam in the emergency department. Effects of a prevention of post\u2010rape stress (PPRS) video and a pleasant imagery and relaxation instruction (PIRI) video were compared with treatment as usual (TAU) during a sexual assault medical forensic exam on PO misuse. Participants reported if they had used POs for non\u2010medical purposes since the sexual assault at 1.5 month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results from a logistic regression analysis indicated that participants with a prior sexual assault were less likely to misuse prescription opioids 1.5 months after the assault in the PIRI condition compared with TAU. There were no main effects for video condition and no interactions for the PPRS condition on PO misuse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Providing the PIRI video, or teaching other types of mindfulness or relaxation exercises, may be warranted as a secondary prevention for individuals during the sexual assault medical forensic exam for those with a prior sexual assault history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>This research provides an initial examination of the impact of mindfulness skills recently after traumatic event exposure on PO misuse. (Am J Addict 2019;28:376\u2013381)<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.12922","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T18:58:40Z","timestamp":1561575520000},"page":"376-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prescription Opioid Misuse After a Recent Sexual Assault: A Randomized Clinical Trial of a Video Intervention"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5376-9206","authenticated-orcid":false,"given":"Amanda K.","family":"Gilmore","sequence":"first","affiliation":[{"name":"Department of Nursing, College of Nursing Medical University of South Carolina  Charleston SC"},{"name":"Department of Psychiatry &amp; Behavioral Sciences Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ferkauf Graduate School of Psychology Yeshiva University  Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Frazier","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Minnesota  Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Ledray","sequence":"additional","affiliation":[{"name":"SANE SART Resource Service  Watertown MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Acierno","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Nursing Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Nursing Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean G.","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi S.","family":"Resnick","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"e_1_2_10_1_2_1","unstructured":"AhrnsbrakR BoseJ HeddenSL et al.Key substance use and mental health indicators in the United States: Results from the 2016 National Survey on Drug Use and Health. 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