{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:45:36Z","timestamp":1792190736671,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["CDC\u2010RFA\u2010PS19\u20101901"],"award-info":[{"award-number":["CDC\u2010RFA\u2010PS19\u20101901"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Congenital syphilis (CS) is increasing in the United States and is associated with intersecting social and structural determinants of health. This study aimed to delineate birthing parent characteristics associated with CS in an adjusted model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods (<jats:italic>n<\/jats:italic>\u2009=\u2009720)<\/jats:title><jats:p>People diagnosed with syphilis during pregnancy from 2017 to 2018 who were interviewed and linked to infants in the California state surveillance system were included (herein, \u201cbirthing parents\u201d). Sociodemographic and clinical CS risk factors informed a stepwise multivariable logistic regression model in which the outcome of interest was infants born with CS. CS prevention continuums delineated the proportion of pregnant people with syphilis who completed steps (e.g., prenatal care entry, syphilis testing, treatment) needed to prevent CS; the outcome was delivering an infant without CS. We stratified continuums by homelessness and methamphetamine use to explore differences in CS outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 720 birthing parents, 245 (34%) delivered an infant with CS. Although CS was initially associated with homelessness (odds ratio [OR]\u2009=\u20092.5, 95% confidence interval [CI]: 1.6, 4.0) and methamphetamine use (OR\u2009=\u20092.1, 95% CI: 1.4, 3.1), the addition of prenatal care into a final adjusted model attenuated these associations to not significant. In CS prevention continuums, delivering an infant without CS was less likely for people who reported methamphetamine use (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and\/or homelessness (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). However, when examining only those who received prenatal care, statistical differences for these predictors no longer existed. In the final adjusted model the following were associated with CS: no prenatal care (OR\u2009=\u200916.7, 95% CI: 9.2, 30.3) or late prenatal care (OR\u2009=\u20092.9, 95% CI: 1.9, 4.2); early stage of syphilis (OR\u2009=\u20092.6, 95% CI: 1.8, 3.7); living in Central California (OR\u2009=\u20092.1, 95% CI: 1.1, 4.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Scientific Significance<\/jats:title><jats:p>This is the first analysis to explore birthing parent characteristics associated with delivering an infant with CS in an adjusted model. We demonstrate that prenatal care, when accessed, can result in effective CS prevention among people who are unhoused and\/or using methamphetamine equally well compared to counterparts without these risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13265","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T07:48:50Z","timestamp":1648367330000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Congenital syphilis prevention in the context of methamphetamine use and homelessness"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-1350","authenticated-orcid":false,"given":"Rosalyn E.","family":"Plotzker","sequence":"first","affiliation":[{"name":"California Department of Public Health Sexually Transmitted Diseases Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases  Richmond California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole O.","family":"Burghardt","sequence":"additional","affiliation":[{"name":"California Department of Public Health Sexually Transmitted Diseases Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases  Richmond California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"Murphy","sequence":"additional","affiliation":[{"name":"California Department of Public Health Sexually Transmitted Diseases Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases  Richmond California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"McLean","sequence":"additional","affiliation":[{"name":"California Department of Public Health Sexually Transmitted Diseases Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases  Richmond California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Jacobson","sequence":"additional","affiliation":[{"name":"California Department of Public Health Sexually Transmitted Diseases Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases  Richmond California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Tang","sequence":"additional","affiliation":[{"name":"California Department of Public Health Sexually Transmitted Diseases Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases  Richmond California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Seidman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003000"},{"key":"e_1_2_8_3_1","unstructured":"Centers for Disease Control and Prevention.Sexually Transmitted Disease Surveillance 2019.\u00a0US Department of Health and Human Services;2019."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2111103"},{"key":"e_1_2_8_5_1","unstructured":"California Department of Public Health.Sexually Transmitted Diseases Control Branch Data 2019. 2020 2021."},{"issue":"1","key":"e_1_2_8_6_1","first-page":"5","article-title":"Efficacy of treatment for syphilis in pregnancy","volume":"93","author":"Alexander JM","year":"1999","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.023655"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000062"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.09.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix371"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6922a1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2018.02.013"},{"key":"e_1_2_8_13_1","unstructured":"California Department of Public Health.Sexually Transmitted Diseases Control Branch. 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