{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:06:04Z","timestamp":1784030764776,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R03DA048913"],"award-info":[{"award-number":["R03DA048913"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and\u00a0Objectives<\/jats:title><jats:p>More information is needed about comorbidities among patients receiving buprenorphine maintenance treatment and their relationship with retention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective electronic health record data over a 5\u2010year period from primary care patients receiving buprenorphine for the treatment of opioid use disorder were examined (<jats:italic>N\u2009<\/jats:italic>=\u2009899). The present analysis determined the prevalence of comorbidities and examined associations with treatment retention as defined by cumulative duration of buprenorphine prescription.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tobacco use and comorbidities including hypertension were prevalent but did not predict retention according to survival analyses controlling for demographic characteristics. Retention was poorer among patients testing positive for cocaine (HR\u2009=\u20091.38, 95% CI:\u00a01.09\u20131.74, <jats:italic>p\u2009=<\/jats:italic>\u2009.007) and patients with hepatitis C virus (HR\u2009=\u20091.17, 95% CI: 1.01\u20131.37, <jats:italic>p\u2009<\/jats:italic>=\u2009.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and\u00a0Scientific Significance<\/jats:title><jats:p>This study provides new knowledge of previously unexamined associations between comorbidities (e.g., hypertension) and buprenorphine treatment retention. The robust association between cocaine use and poorer buprenorphine retention serves to resolve prior conflicting data in the literature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13268","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T10:53:38Z","timestamp":1649242418000},"page":"256-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Buprenorphine treatment retention and comorbidities among patients with opioid use disorder in a primary care setting"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-4321","authenticated-orcid":false,"given":"Mary M.","family":"Sweeney","sequence":"first","affiliation":[{"name":"Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6029-6902","authenticated-orcid":false,"given":"Laura","family":"Prichett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Biostatistics, Epidemiology, and Data Management Core Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-6215","authenticated-orcid":false,"given":"Michael I.","family":"Fingerhood","sequence":"additional","affiliation":[{"name":"Department of Medicine,\u00a0Division of Addiction Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Antoine","sequence":"additional","affiliation":[{"name":"Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Umbricht","sequence":"additional","affiliation":[{"name":"Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-7682","authenticated-orcid":false,"given":"Megan E.","family":"Buresh","sequence":"additional","affiliation":[{"name":"Department of Medicine,\u00a0Division of Addiction Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"CD002207","article-title":"Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence","author":"Mattick RP","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n784"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/pop.2018.0163"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2021.108548"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201700363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2016.12.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232086"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2018.0526"},{"key":"e_1_2_8_10_1","unstructured":"RuiP OkeyodeT. National Ambulatory Medical Care Survey: 2016 National Summary Tables.https:\/\/www.cdc.gov\/nchs\/data\/ahcd\/namcs_summary\/2016_namcs_web_tables.pdf"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp186"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajad.13268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:39:14Z","timestamp":1692985154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.13268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/ajad.13268"],"URL":"https:\/\/doi.org\/10.1111\/ajad.13268","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]},"assertion":[{"value":"2021-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}