{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:59:24Z","timestamp":1740128364957,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA16672"],"award-info":[{"award-number":["P30CA16672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Bupropion extended\u2010release (XL; once\u2010daily dosing) has equal efficacy with the sustained\u2010release (SR) formulation (twice\u2010daily dosing) for treating depression, but no studies have compared the two formulations for the treatment of smoking. In a naturalistic open\u2010label study, we compared the effectiveness and the adverse event profiles of XL and SR in treating cancer patients for smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cancer patients (<jats:italic>N<\/jats:italic>\u2009=\u2009648) were prescribed bupropion XL (<jats:italic>n<\/jats:italic>\u2009=\u2009454) or SR (<jats:italic>n<\/jats:italic>\u2009=\u2009194) alone or in combination with nicotine replacement therapy (NRT) for treating smoking from September 2006 to December 2017. We analyzed 7\u2010day point prevalence abstinence at end\u2010of\u2010treatment (EOT; 3 months postmedication initiation) and evaluated for noninferiority. We also analyzed the adverse event profile differences between the medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in abstinent rates at EOT between bupropion XL and SR when using intent\u2010to\u2010treat models, regardless of concomitant NRT. XL demonstrated noninferiority in treatment efficacy compared to SR when excluding those on combined treatment with NRT. Further, there were no significant differences in spontaneously reported adverse events between XL and SR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data did not reveal a difference between bupropion XL and SR formulations in terms of effectiveness or adverse event profiles among cancer patients prescribed bupropion alone or in combination with NRTs to quit smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>In this first published direct comparison of their effectiveness and adverse event profiles, we found that bupropion XL is likely therapeutically equivalent to bupropion SR when treating smoking among cancer patients, and produces similar side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13282","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T03:34:35Z","timestamp":1648524875000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bupropion XL and SR have similar effectiveness and adverse event profiles when used to treat smoking among patients at a comprehensive cancer center"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1588-9637","authenticated-orcid":false,"given":"Jason D.","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher","family":"Karam\u2010Hage","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Kypriotakis","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Beneventi","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice A.","family":"Blalock","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-271X","authenticated-orcid":false,"given":"Yong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Tayar","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Chaftari","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Cinciripini","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1994.43"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0803"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125316629071"},{"issue":"3","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1742-1241.2003.tb10468.x","article-title":"Efficacy and safety of bupropion SR for smoking cessation: data from clinical trials and five years of postmarketing experience","volume":"57","author":"Ferry L","year":"2003","journal-title":"Int J Clin Pract"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2015.1117480"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2012.705016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595230100100642"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.11.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mjt.0000208273.80496.3f"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v07n0305"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0153"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0152"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.18.1737"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntr137"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1995.56.423"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1037\/0893-164X.12.2.101"},{"key":"e_1_2_8_20_1","unstructured":"US Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE): Version 5.0.\u00a0Accessed August 25 2021.\u00a0https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_5x7.pdf"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00111-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.62.3.569"},{"key":"e_1_2_8_23_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research. Guidance for industry non\u2010inferiority clinical trials.\u00a0Accessed January 9 2020.\u00a0https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/non-inferiority-clinical-trials"},{"key":"e_1_2_8_24_1","first-page":"CD000031","article-title":"Antidepressants for smoking cessation","volume":"4","author":"Howes S","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.20br02621"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.11.005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1309"},{"key":"e_1_2_8_28_1","article-title":"Pharmacological interventions for smoking cessation: an overview and network meta\u2010analysis","volume":"5","author":"Cahill K","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000329"},{"key":"e_1_2_8_30_1","first-page":"CD009504","article-title":"Bupropion for attention deficit hyperactivity disorder (ADHD) in adults","volume":"10","author":"Verbeeck W","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181a5233f"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3421"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntw140"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001015"},{"key":"e_1_2_8_35_1","first-page":"CD006102","article-title":"Smoking cessation interventions for smokers with current or past depression","volume":"8","author":"Meer RM","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.12251"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajad.13282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:38:40Z","timestamp":1692985120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.13282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/ajad.13282"],"URL":"https:\/\/doi.org\/10.1111\/ajad.13282","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"type":"print","value":"1055-0496"},{"type":"electronic","value":"1521-0391"}],"subject":[],"published":{"date-parts":[[2022,3,28]]},"assertion":[{"value":"2021-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}