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Prior reviews examining these conditions are now nearly a decade old, have focused on younger adolescent populations, or have utilized nonsystematic approaches. To our knowledge, no prior reviews have reported on all three of these domains in an integrated fashion. Here, we provide a contemporary, critical synthesis of the literature on the functioning of TAY\u2010EH in North America within these three domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based upon PRISMA guidelines, a search of PubMed, Medline, and PsycInfo databases was conducted, including literature published between January 2015 and June 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial search yielded 2024 citations; 104 underwent full text review and 32 met inclusion criteria, with a final aggregate sample size of 13,516. Studies revealed elevated rates of mood disorders, PTSD, anxiety disorders, and alcohol misuse. There is insufficient data to draw generalizable conclusions regarding neuropsychological functioning, other SUD, or other psychiatric diagnoses. No studies reported on co\u2010occurrence of disorders among or between the domains of psychopathology, SUD, and neuropsychological dysfunction. Four studies used structured interviews for diagnoses, with the remainder relying upon brief screeners or self\u2010report measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Scientific Significance<\/jats:title><jats:p>To our knowledge, this is the first systematic review to provide integrated findings on psychopathology, SUD, and neuropsychological dysfunction among TAY\u2010EH. Further research using structured, DSM\u2010based tools is needed to characterize rates of single and co\u2010occurring conditions to inform tailored treatment interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13340","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T10:07:54Z","timestamp":1661767674000},"page":"523-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Systematic review: Rates of psychopathology, substance misuse, and neuropsychological dysfunction among transitional age youth experiencing homelessness"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8658-2632","authenticated-orcid":false,"given":"Colin W.","family":"Burke","sequence":"first","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Firmin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"Wilens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2017.10.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1909"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.97.3.289"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10935-018-0511-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-2674"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2014.04.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2013.301318"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-011-0270-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/16.6.e43"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2016.1207758"},{"key":"e_1_2_7_12_1","unstructured":"FreyW. 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