{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:58:45Z","timestamp":1788307125661,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K99AA029732"],"award-info":[{"award-number":["K99AA029732"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["T32AA025877"],"award-info":[{"award-number":["T32AA025877"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA035167"],"award-info":[{"award-number":["T32DA035167"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Adverse events during childhood increase the risk for the development of substance use disorders (SUDs). This study examined the association between adverse childhood experiences (ACEs) and SUD treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort analysis included data from longitudinal clinical assessments extracted from the records of 438 consenting individuals undergoing SUD treatment (63% male; 88.8% White). Mixed effects models evaluated the relationship between scores on the ACE questionnaire and indicators of treatment response (i.e., alcohol and drug abstinence self\u2010efficacy; symptoms of depression, anxiety, and posttraumatic stress disorder) for individuals with alcohol\u2010related (<jats:italic>n<\/jats:italic>\u2009=\u2009332) and other drug\u2010related (<jats:italic>n<\/jats:italic>\u2009=\u2009275) diagnoses, with some participants included in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment response varied as a function of ACEs, with the magnitude of differences varying across time in treatment. Relative to those with no ACE history, those who experienced \u22652 ACEs reported worse depression, anxiety, PTSD symptoms, and alcohol\/drug abstinence self\u2010efficacy at baseline, with many differences remaining at the 30\u2010day assessment. All differences abated by discharge, with the exception of PTSD symptoms among those in the drug use group with a history of \u22654 ACEs. Male gender and older age were generally associated with lower symptomology and higher abstinence self\u2010efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Assessing ACE history early in SUD treatment may improve treatment planning and prognosis. Future studies should evaluate the role of trauma\u2010informed programming and individual interventions to improve treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>This study demonstrates the association between adverse childhood experiences and symptom severity among patients across participation in SUD treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13366","type":"journal-article","created":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T10:09:10Z","timestamp":1671962950000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The association between adverse childhood experiences and treatment response for adults with alcohol and other drug use disorders"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-7014","authenticated-orcid":false,"given":"Benjamin","family":"Borgert","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-4481","authenticated-orcid":false,"given":"Deborah G.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian M.","family":"Rung","sequence":"additional","affiliation":[{"name":"Department of Health Education and Behavior University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Teitelbaum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3613-7853","authenticated-orcid":false,"given":"Lisa J.","family":"Merlo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4603(01)00204-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.8.1453"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01157-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01491.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.02.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2004.08.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2007.01.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0015355"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2013.09.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1263161"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1994.55.141"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22059"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2017-037"},{"key":"e_1_2_7_20_1","unstructured":"KassambaraA. rstatix: pipe\u2010friendly framework for basic statistical tests. R package version (0.7.0);2021. Accessed August 13 2022.https:\/\/cran.r-project.org\/package=rstatix"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"issue":"1","key":"e_1_2_7_22_1","first-page":"1","article-title":"HLMdiag: a suite of diagnostics for hierarchical linear models in R","volume":"56","author":"Loy A","year":"2014","journal-title":"J Stat Softw"},{"key":"e_1_2_7_23_1","volume-title":"An {R} Companion to Applied Regression","author":"Fox J","year":"2019"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_7_25_1","unstructured":"KassambaraA. ggpubr: \u201cggplot2\u201d Based Publication Ready Plots R package version 0.4.0; 2020.https:\/\/cran.r-project.org\/package=ggpubr"},{"key":"e_1_2_7_26_1","unstructured":"HlavacM. stargazer: Well\u2010Formatted Regression and Summary Statistics Tables R package R package version 5.2.2; 2018.https:\/\/CRAN.R-project.org\/package=stargazer"},{"key":"e_1_2_7_27_1","unstructured":"National Survey on Drug Use and Health.2016\u20132017 NSDUH State Prevalence Estimates. National Survey on Drug Use and Health;2018."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.73.6.1175"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0026917"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.00218.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0740-5472(92)90067-X"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.10.007"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcop.20063"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajad.13366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:47:52Z","timestamp":1692586072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.13366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,25]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/ajad.13366"],"URL":"https:\/\/doi.org\/10.1111\/ajad.13366","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,25]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}