{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:10:15Z","timestamp":1791825015709,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Childhood trauma (CT) increases addiction vulnerability. We examined CT's impact on delta\u20109\u2010tetrahydrocannabinol (THC) effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a post\u2010hoc analysis of a randomized, placebo\u2010controlled, crossover trial investigating the effects of oral THC (10, 20\u2009mg) among 25 persons receiving methadone for opioid use disorder (OUD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Greater CT was associated with lower aversive effects from higher THC doses (20\u2009mg) (<jats:italic>p<\/jats:italic>\u2009=\u2009.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>CT may reduce the subjective aversive effects of THC, potentially leading to greater cannabis use in individuals with OUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>These findings offer insights into THC's risks versus benefits in OUD subgroups and emphasize assessing CT in OUD treatment and research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13504","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T04:24:46Z","timestamp":1702009486000},"page":"343-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Brief report: The influence of childhood trauma on the effects of delta\u20109\u2010tetrahydrocannabinol in persons with opioid use disorder"],"prefix":"10.1111","volume":"33","author":[{"given":"Michael","family":"Rogan","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"VISN\u20101 Mental Illness Research Education and Clinical Center (MIRECC) VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"VISN\u20101 Mental Illness Research Education and Clinical Center (MIRECC) VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Z.","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Counseling and Developmental Psychology Boston College Chestnut Hill Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sofuoglu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"VISN\u20101 Mental Illness Research Education and Clinical Center (MIRECC) VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-8215","authenticated-orcid":false,"given":"Joao P.","family":"De Aquino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"VISN\u20101 Mental Illness Research Education and Clinical Center (MIRECC) VA Connecticut Healthcare System West Haven Connecticut USA"},{"name":"Clinical Neuroscience Research Unit Connecticut Mental Health Center New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Institutes of Health National Institute on Drug Abuse. Drug overdose death rates2023.https:\/\/nida.nih.gov\/research-topics\/trends-statistics\/overdose-death-ratesates. 2023. Accessed June 23 2023."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.109097"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2018.0022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.0266"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13047"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108416"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13317"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8634176"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20190026"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17040413"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T11:32:48Z","timestamp":1713612768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.13504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ajad.13504"],"URL":"https:\/\/doi.org\/10.1111\/ajad.13504","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,7]]},"assertion":[{"value":"2023-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}