{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:56:43Z","timestamp":1788973003253,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015728","name":"Clinical Science Research and Development","doi-asserted-by":"publisher","award":["1 I01 CX001517\u201001"],"award-info":[{"award-number":["1 I01 CX001517\u201001"]}],"id":[{"id":"10.13039\/100015728","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>There are high rates of comorbidity between posttraumatic stress disorder (PTSD) and opioid use disorder (OUD). Evidence\u2010based trauma\u2010focused psychotherapies such as Cognitive Processing Therapy (CPT) are a first\u2010line treatment for PTSD. Veterans with OUD are treated primarily in substance use disorder (SUD) clinics where the standard of care is drug counseling; they often do not have access to first\u2010line PTSD treatments. This study tested whether CPT can be conducted safely and effectively in veterans with comorbid OUD treated with buprenorphine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This 12\u2010week, 2\u2010site, randomized clinical trial (RCT) included open\u2010label randomization to two groups: (a) CPT versus (b) Individual Drug Counselling (IDC) in veterans with PTSD and comorbid OUD who were maintained on buprenorphine (<jats:italic>N<\/jats:italic>\u2009=\u200938).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Veterans randomized to either IDC (<jats:italic>n<\/jats:italic>\u2009=\u200918) or CPT (<jats:italic>n<\/jats:italic>\u2009=\u200920) showed a significant reduction in self\u2010reported PTSD symptoms over time as measured by the PTSD checklist (PCL\u20105) but there were no treatment group differences; there was some indication that reduction in PTSD symptoms in the CPT group were sustained in contrast to the IDC group. Recruitment was significantly impacted by COVID\u201019 pandemic, so this study serves as a proof\u2010of\u2010concept pilot study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusions<\/jats:title><jats:p>Veterans with OUD and PTSD can safely and effectively participate in evidence\u2010based therapy for PTSD; further work should confirm that trauma\u2010focused treatment may be more effective in leading to sustained remission of PTSD symptoms than drug counseling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Scientific Significance<\/jats:title><jats:p>This is the first study to evaluate CPT for PTSD in the context of buprenorphine treatment for OUD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13557","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T15:16:03Z","timestamp":1713280563000},"page":"525-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-5946","authenticated-orcid":false,"given":"Ismene L.","family":"Petrakis","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Department of Psychiatry VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Meshberg\u2010Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Department of Psychiatry VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charla","family":"Nich","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Psychiatry VA Bedford Healthcare System Bedford Massachusetts USA"},{"name":"Department of Psychiatry UMass Chan Medical School North Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Claudio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry VA Bedford Healthcare System Bedford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Serrita","family":"Jane","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Department of Psychiatry VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Department of Psychiatry VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0144-4079","authenticated-orcid":false,"given":"Elizabeth","family":"Ralevski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Department of Psychiatry VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"SchnurrPPEpidemiology and Impact of PTSD.2024. 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