{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:29:15Z","timestamp":1791016155699,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal opioid withdrawal syndrome (NOWS) is a drug withdrawal syndrome occurring mainly after in utero opioid exposure. Buprenorphine is commonly used for opioid withdrawal. Studies are conflicted about a potential dose effect<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to investigate the impact of buprenorphine maternal maintenance therapy on the NOWS based on NOWS duration, birth weight and therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>We conducted a retrospective study analysing data from infants admitted for NOWS in two Neonatal Intensive Care Unit between January 2010 and December 2020. Inclusion criteria: Nonpreterm infants born to mothers who were treated with buprenorphine or therapy during pregnancy and who had a Lipsitz score of 4 or higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 75 term newborns were hospitalized for the treatment of NOWS from mother substituted with buprenorphine during the study inclusion period. The duration of NOWS differed significantly between all dose cohorts, with higher doses of maternal buprenorphine maintenance correlating with longer length of NOWS duration. Infants exposed to high doses required 17 days [10; 23], while infants exposed to intermediate doses required 7 days [2; 16] and infants exposed to low doses required 3 days [2; 5], with <jats:italic>p<\/jats:italic>\u2010values\u2009&lt;\u2009.003. Infants exposed to high doses required a longer time to regain their birth weight and higher morphine doses as therapy compared to others. Infants exposed to low doses, intermediate doses, and high doses of buprenorphine demonstrated dose\u2010dependent increases in the durations of hospitalization, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Scientific Significance<\/jats:title><jats:p>Increased doses of maternal buprenorphine during pregnancy are correlated with NOWS severity. Our study shows that increased doses of maternal buprenorphine during pregnancy are correlated with NOWS severity. Exploring low doses and having different ranges are a new argument to define the impact of maternal buprenorphine consumption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13652","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T09:19:26Z","timestamp":1727601566000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is buprenorphine maternal dose associated with neonatal opioid withdrawal syndrome severity?"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-2580","authenticated-orcid":false,"given":"Besnier","family":"Marc","sequence":"first","affiliation":[{"name":"University of Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delouche","family":"Marion","sequence":"additional","affiliation":[{"name":"University of Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birault","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"University of Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lebonheur","family":"Lakshmipriya","sequence":"additional","affiliation":[{"name":"University of Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"113","article-title":"Neonatal abstinence syndrome: recognition and diagnosis","volume":"2","author":"Desmond MM","year":"1975","journal-title":"Addict Dis"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"141","article-title":"Neonatal abstinence syndrome: assessment and management","volume":"2","author":"Finnegan LP","year":"1975","journal-title":"Addict Dis"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992287501400613"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-115300"},{"key":"e_1_2_8_6_1","first-page":"144","article-title":"Enqu\u00eate sur les femmes enceintes substitu\u00e9es \u00e0 la m\u00e9thadone ou \u00e0 la bupr\u00e9norphine haut dosage et caract\u00e9ristiques de leurs nouveau\u2010n\u00e9s","volume":"7","author":"Lejeune C","year":"2003","journal-title":"OFDT"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"37","article-title":"Opioid prescription claims among women of reproductive age: United States, 2008\u20102012","volume":"64","author":"Ailes EC","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6531a2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000166"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2010.0038"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"177","article-title":"[Pregnancy, abortion and delivery in a cohort of heroin dependent patients treated with drug substitution (methadone and buprenorphine) in Aquitaine]","volume":"28","author":"Auriacombe M","year":"1999","journal-title":"Presse Med"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0437-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2022.2130238"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002054"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721693"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.156"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.11.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441220"},{"issue":"1","key":"e_1_2_8_19_1","article-title":"Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome","volume":"2","author":"Lappen JR","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1608783"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000427"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-200645"},{"key":"e_1_2_8_23_1","unstructured":"DavisNL SmootsAN GoodmanDA. Pregnancy\u2010related deaths: data from 14 U.S. Maternal Mortality Review Committees 2008\u20102017 [Internet]. Centers for Disease Control and Prevention;2019.https:\/\/www.cdc.gov\/reproductivehealth\/maternal-mortality\/erase-mm\/MMR-Data-Brief_2019-h.pdf"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.17128"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-282-1:01"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08725"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3299"},{"key":"e_1_2_8_28_1","first-page":"143","article-title":"Management of opioid addiction with buprenorphine: French history and current management","volume":"7","author":"Polomeni P","year":"2014","journal-title":"Int J Gen Med"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.07.037"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000562"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-007-0046-2"},{"key":"e_1_2_8_32_1","volume-title":"StatPearls","author":"Preuss CV","year":"2021"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2013.02.001"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","unstructured":"DookeranKA FefferMG QuigleyKM TrollerPE ChristmonCA KhanJYDisparity in neonatal abstinence syndrome by race\/ethnicity socioeconomic status and geography in neonates \u226535 weeks gestational age.PLoS One.2023;18(4):e0284040.doi:10.1371\/journal.pone.0284040","DOI":"10.1371\/journal.pone.0284040"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01440-5"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1357970"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2024.2337711"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01116-3"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000945"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abrep.2020.100315"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002229"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2024.04.003"},{"issue":"01","key":"e_1_2_8_43_1","first-page":"e2225","article-title":"Evaluating the association between prenatal care visits and adverse perinatal outcome in pregnancies complicated by opioid use disorder","volume":"41","author":"Pinchman EV","year":"2023","journal-title":"Am J Perinatol"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-015-0037-2"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T12:27:19Z","timestamp":1735302439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.13652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,29]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ajad.13652"],"URL":"https:\/\/doi.org\/10.1111\/ajad.13652","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,29]]},"assertion":[{"value":"2024-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}