{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T04:06:12Z","timestamp":1746245172531,"version":"3.40.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K01DA046715","T32DA035167"],"award-info":[{"award-number":["K01DA046715","T32DA035167"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR001428","UL1TR001427"],"award-info":[{"award-number":["TL1TR001428","UL1TR001427"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Nonmedical use of prescription tranquilizers\/sedatives (NMUPTS) is associated with a 15\u2010times increased likelihood of polysubstance use (PSU). This is correlated with an increased risk for use disorders and death, therefore, to inform prevention efforts, we identified PSU profiles among adults reporting sleep\u2010related NMUPTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>National Survey on Drug Use and Health 2015\u20132019 participants with past 12\u2010month sleep\u2010related NMUPTS and use of an additional drug(s) (<jats:italic>n\u2009<\/jats:italic>=\u20092603) were studied. Latent class analyses identified unique latent profiles, and multivariable logistic regressions identified covariates associated with each profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol (90.4%), tobacco (61.5%), and marijuana (55.5%) were most commonly reported, with an average of 3.6 additional substances. Two latent PSU profiles were identified: marijuana\/alcohol\/tobacco (MAT) (68.3%) and MAT\u2009+\u2009cocaine\/hallucinogens\/prescription drugs (MAT\u2009+\u2009CHPR) (31.7%). In comparison to those likely in the MAT profile, those likely in the MAT\u2009+\u2009CHPR profile had lower odds of being older than 18\u201325 years (26\u201334: adjusted odds ratio [AOR]: 0.5, 95% confidence interval [CI]: 0.3, 0.6; 35\u201349: AOR: 0.2, 95% CI: 0.1, 0.2; 50+: AOR: 0.1, 95% CI: 0.0, 0.1), female (AOR: 0.4, 95% CI: 0.3, 0.6), non\u2010Hispanic Black (AOR: 0.5, 95% CI: 0.4, 0.8) or Hispanic in comparison to non\u2010Hispanic White (AOR: 0.5, 95% CI: 0.4, 0.8), and to not have past 12\u2010month insurance coverage (AOR: 1.7, 95% CI: 1.3, 2.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Scientific Significance<\/jats:title><jats:p>Two PSU profiles were identified among people with NMUPTS, with noted variations in sociodemographic characteristics. In comparison to previous studies, sleep\u2010related NMUPTS was associated with higher rates of stimulant use, suggesting stimulant use and sleep\u2010related NMUPTS may be related.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.13665","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T02:24:56Z","timestamp":1731378296000},"page":"313-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Profiles of polysubstance use among people reporting past 12\u2010month sleep\u2010motivated nonmedical use of prescription tranquilizers\/sedatives"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9488-3710","authenticated-orcid":false,"given":"Alyssa M.","family":"Falise","sequence":"first","affiliation":[{"name":"Department of Epidemiology College of Public Health &amp; Health Professions and College of Medicine, University of Florida Gainesville Florida USA"},{"name":"American College of Medical Toxicology Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvathy","family":"Prasanna Surendran","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health &amp; Health Professions and College of Medicine, University of Florida Gainesville Florida USA"},{"name":"Department of Otolaryngology Mayo Clinic College of Medicine &amp; Science Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1741-9671","authenticated-orcid":false,"given":"Carolin C.","family":"Hoeflich","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health &amp; Health Professions and College of Medicine, University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine W.","family":"Striley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health &amp; Health Professions and College of Medicine, University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liva","family":"LaMontagne","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health &amp; Health Professions and College of Medicine, University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Lopez\u2010Quintero","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health &amp; Health Professions and College of Medicine, University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"issue":"436","key":"e_1_2_8_2_1","first-page":"1","article-title":"Sleep difficulties in adults: United States, 2020","author":"Adjaye\u2010Gbewonyo D","year":"2022","journal-title":"NCHS Data Brief"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.2147\/NSS.S163071"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.2147\/NSS.S134864"},{"issue":"6","key":"e_1_2_8_5_1","first-page":"843","article-title":"Recommended amount of sleep for a healthy adult: a joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society","volume":"38","author":"Watson NF","year":"2015","journal-title":"Sleep"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1001\/jamanetworkopen.2022.43215"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/j.amjmed.2018.09.021"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1176\/appi.ps.201800321"},{"unstructured":"Substance Abuse and Mental Health Services. Key substance use and mental health indicators in the United States: results from the 2021 National Survey on Drug Use and Health.2021. Accessed March 1 2024.\u00a0https:\/\/www.samhsa.gov\/data\/report\/2021-nsduh-annual-national-report","key":"e_1_2_8_9_1"},{"volume-title":"2020 National Survey on Drug Use and Health (NSDUH): Methodological Summary and Definitions","year":"2021","author":"Center for Behavioral Health Statistics and Quality","key":"e_1_2_8_10_1"},{"unstructured":"Center for Behavioral Health Statistics and Quality. 2017 National Survey on Drug Use and Health: detailed tables. 2018. Accessed March 1 2024.https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/cbhsq-reports\/NSDUHDetailedTabs2017\/NSDUHDetailedTabs2017.pdf","key":"e_1_2_8_11_1"},{"issue":"6","key":"e_1_2_8_12_1","article-title":"Benzodiazepine misuse: an epidemic within a pandemic","volume":"13","author":"Sarangi A","year":"2021","journal-title":"Cureus"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.15585\/mmwr.mm7034a2"},{"unstructured":"Centers for Disease Control and Prevention. Polysubstance use facts. September 20 2022. Accessed August 10 2023.https:\/\/www.cdc.gov\/stopoverdose\/polysubstance-use\/index.html","key":"e_1_2_8_14_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1080\/10826084.2019.1708118"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1111\/ajad.13481"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1016\/j.drugpo.2017.05.016"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1186\/s13722-016-0056-7"},{"unstructured":"NSDUH. Confidentiality. Accessed October 9 2024.https:\/\/nsduhweb.rti.org\/RespWeb\/confidentiality.html","key":"e_1_2_8_19_1"},{"unstructured":"Center for Behavioral Health Statistics and Quality. 2019 National Survey on Drug Use and Health Public Use File Codebook. 2020. Accessed February 10 2024.https:\/\/www.datafiles.samhsa.gov\/sites\/default\/files\/field-uploads-protected\/studies\/NSDUH-2019\/NSDUH-2019-datasets\/NSDUH-2019-DS0001\/NSDUH-2019-DS0001-info\/NSDUH-2019-DS0001-info-codebook.pdf","key":"e_1_2_8_20_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1093\/pan\/mpq025"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1177\/0095798420930932"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1080\/10705511.2014.915375"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1080\/10705511.2014.915181"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1016\/j.pbb.2021.173169"},{"issue":"12","key":"e_1_2_8_26_1","first-page":"358","article-title":"Benzodiazepine and unhealthy alcohol use among adult outpatients","volume":"25","author":"Hirschtritt ME","year":"2019","journal-title":"Am J Manag Care"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.17116\/jnevro2020120051153"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.1097\/ADM.0000000000000932"},{"doi-asserted-by":"publisher","key":"e_1_2_8_29_1","DOI":"10.1111\/ajad.13465"},{"doi-asserted-by":"publisher","key":"e_1_2_8_30_1","DOI":"10.1097\/ADM.0000000000000292"},{"doi-asserted-by":"publisher","key":"e_1_2_8_31_1","DOI":"10.1016\/j.addbeh.2020.106608"},{"doi-asserted-by":"publisher","key":"e_1_2_8_32_1","DOI":"10.1007\/978-981-16-0123-1_40"},{"doi-asserted-by":"publisher","key":"e_1_2_8_33_1","DOI":"10.1016\/j.psc.2015.07.008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_34_1","DOI":"10.1038\/s41386-019-0465-x"},{"unstructured":"Substance Abuse and Mental Health Services. Why does SAMHSA caution against comparing 2020 estimates with estimates from other years? CBHSQ data. Accessed September 1 2024.https:\/\/www.samhsa.gov\/data\/faq\/concerns-about-trend-comparability\/why-does-samhsa-caution-against-comparing-2020-estimates-estimates-prior-years","key":"e_1_2_8_35_1"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.13665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:24:16Z","timestamp":1746188656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.13665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/ajad.13665"],"URL":"https:\/\/doi.org\/10.1111\/ajad.13665","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"type":"print","value":"1055-0496"},{"type":"electronic","value":"1521-0391"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"2024-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}