{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:21:30Z","timestamp":1789136490117,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The United States has been experiencing a deadly epidemic of fatal drug overdose (OD), including among emerging\/young adults. We aimed to examine intentional OD (IOD) among young adults receiving methadone maintenance treatment for opioid use disorders (OUD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty\u2010three participants (18\u201326 years old) with OUD completed measures of drug use, OD, depression, and suicidal behavior. Between\u2010group differences were analyzed using independent samples <jats:italic>t<\/jats:italic>\u2010test and \u03c7\u00b2 test for continuous and dichotomous data, respectively. Regression analysis was employed to predict the magnitude of intent to die before the most recent OD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two percent of the sample had a history of a suicide attempt (SA). Of those, 78% reported &gt;1 IOD. Participants with SA history had a significantly higher depression severity (<jats:italic>p<\/jats:italic>\u2009=\u2009.01), were younger at the onset of opioid use (<jats:italic>p<\/jats:italic>\u2009=\u2009.04) and were less likely to be Hispanic (<jats:italic>p<\/jats:italic>\u2009=\u2009.03) relative to those without SA history. The magnitude of intent to die before the most recent OD was predicted by (a) number of lifetime SAs (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), (b) likelihood that participant thought they would OD before their most recent OD (<jats:italic>p<\/jats:italic>\u2009=\u2009.009), and (c) number of days using illicit opioids in the last 30 (<jats:italic>p<\/jats:italic>\u2009=\u2009.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Scientific Significance<\/jats:title><jats:p>These findings indicate a high prevalence of IOD among young adults enrolled in clinical services. Awareness of suicidal intent as a predictor of OD would improve prevention\u2010intervention methods for the reduction of morbidity and mortality among them. This is the first reported study to examine IOD among emerging\/young adults with OUD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajad.70026","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T03:59:17Z","timestamp":1741665557000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug overdose and suicidal intentionality among young adults in methadone treatment"],"prefix":"10.1111","volume":"34","author":[{"given":"Yifrah","family":"Kaminer","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-7062","authenticated-orcid":false,"given":"Simon","family":"Zhornitsky","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"CDC. 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