{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T07:42:12Z","timestamp":1761982932994,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Patients with cirrhosis face poor outcomes for numerous acute pathologies, but opioid withdrawal outcomes in this population are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross\u2010sectional study of 306,455 hospitalizations for opioid withdrawal within the National Inpatient Sample from 2016 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with cirrhosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092415) had increased rates of mechanical ventilation (aOR\u2009=\u20092.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004), death (aOR\u2009=\u20094.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.022) and cost (mean $7845 vs. $4409,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Scientific Significance<\/jats:title>\n                    <jats:p>This is the first large, generalizable study of opioid withdrawal in cirrhosis, showing worse outcomes and underscoring the need for careful monitoring in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajad.70066","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:34:20Z","timestamp":1752071660000},"page":"678-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brief report: Opioid withdrawal in patients with cirrhosis: A retrospective cross\u2010sectional United States analysis"],"prefix":"10.1111","volume":"34","author":[{"given":"Christopher","family":"Behrend","sequence":"first","affiliation":[{"name":"Department of Medicine Hennepin Healthcare Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra D.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota Medical School Twin Cities Campus Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-2670","authenticated-orcid":false,"given":"Spencer R.","family":"Goble","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition University of Minnesota Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: Results from the 2023 National Survey on Drug Use and Health (HHS Publication No. PEP24\u201007\u2010021 NSDUH Series H\u201059). Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration; 2024.https:\/\/www.samhsa.gov\/data\/report\/2023-nsduh-annual-national-report"},{"volume-title":"StatPearls","year":"2025","author":"Shah M","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15818"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001228"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13594"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2018-000271"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.07.029"},{"issue":"8","key":"e_1_2_7_9_1","first-page":"514","article-title":"Precipitating factors and the outcome of hepatic encephalopathy in liver cirrhosis","volume":"20","author":"Mumtaz K","year":"2010","journal-title":"J Coll Phys Surg Pak"},{"issue":"1","key":"e_1_2_7_10_1","first-page":"1","article-title":"Precipitating factors and outcome of hepatorenal syndrome In liver cirrhosis","volume":"71","author":"Chinnasamy V","year":"2023","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2023.10.022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06051-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.04.034"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201507-448BC"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-020-0707-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-006-9109-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.08.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521288"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.70066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T07:39:14Z","timestamp":1761982754000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.70066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/ajad.70066"],"URL":"https:\/\/doi.org\/10.1111\/ajad.70066","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"type":"print","value":"1055-0496"},{"type":"electronic","value":"1521-0391"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}