{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:12:06Z","timestamp":1787605926064,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["CA252185"],"award-info":[{"award-number":["CA252185"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015615","name":"National Drug Abuse Treatment Clinical Trials Network","doi-asserted-by":"publisher","award":["The Pacific Northwest Node (U10 DA01714)"],"award-info":[{"award-number":["The Pacific Northwest Node (U10 DA01714)"]}],"id":[{"id":"10.13039\/100015615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Tobacco smoking and alcohol use disorder (AUD) are highly prevalent among individuals receiving medication for opioid use disorder (MOUD) treatment, yet their combined impact on treatment outcomes remains underexplored. This study investigates the differences in clinical profiles and treatment outcomes based on smoking and AUD status among individuals initiating MOUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This secondary analysis utilized data from a multi\u2010site randomized clinical trial (CTN\u20100027) evaluating the hepatotoxicity during 24 weeks of buprenorphine or methadone treatment. Participants were categorized into four groups based on baseline smoking and AUD status: Non\u2010AUD\/Non\u2010smoker, Smoker Only, AUD Only, and AUD+Smoker. Clinical profiles and treatment outcomes were compared across groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 973 participants (68.6% male, 70.5% White, mean age 37.5 years), 50% were Smoker Only, 16% AUD+Smoker, 8% AUD Only, and 27% Non\u2010AUD\/Non\u2010smoker. Smoking prevalence was high (66%), while AUD prevalence was lower (24%). AUD+Smoker and AUD Only groups had significantly higher rates of additional substance use disorders (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). However, treatment outcomes\u2014measured by urinalysis results, retention, and completion\u2014did not differ significantly across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Smoking and AUD status were not associated with poorer MOUD outcomes, but the high prevalence of smoking, and the clustering of additional substance use disorders among individuals with AUD suggest the need for integrated care. These findings support inclusion of adjunctive behavioral and public health interventions within MOUD programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Scientific Significance<\/jats:title>\n                    <jats:p>This study uniquely examines the joint impact of smoking and AUD on MOUD outcomes, offering insight into clinical complexity not previously explored in combination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajad.70075","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T02:34:38Z","timestamp":1755138878000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring clinical profile and treatment outcome differences based on baseline smoking and alcohol co\u2010use status among individuals initiating medication for opioid use disorder treatment"],"prefix":"10.1111","volume":"35","author":[{"given":"Gabriela","family":"Le\u00f3n","sequence":"first","affiliation":[{"name":"Washington State University Elson S. Floyd College of Medicine Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Bae","sequence":"additional","affiliation":[{"name":"Washington State University Elson S. Floyd College of Medicine Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-2094","authenticated-orcid":false,"given":"Cari","family":"Coles","sequence":"additional","affiliation":[{"name":"Washington State University Elson S. Floyd College of Medicine Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Batts","sequence":"additional","affiliation":[{"name":"Washington State University Elson S. Floyd College of Medicine Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Washington State University Analytics &amp; Psychopharmacology Laboratory (APPL) Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Akana","sequence":"additional","affiliation":[{"name":"Washington State University Analytics &amp; Psychopharmacology Laboratory (APPL) Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-2822","authenticated-orcid":false,"given":"Crystal L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Washington State University Elson S. Floyd College of Medicine Spokane Washington USA"},{"name":"Washington State University Analytics &amp; Psychopharmacology Laboratory (APPL) Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling M.","family":"McPherson","sequence":"additional","affiliation":[{"name":"Washington State University Elson S. Floyd College of Medicine Spokane Washington USA"},{"name":"Washington State University Analytics &amp; Psychopharmacology Laboratory (APPL) Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-3889","authenticated-orcid":false,"given":"Andr\u00e9 C.","family":"Miguel","sequence":"additional","affiliation":[{"name":"Washington State University Elson S. Floyd College of Medicine Spokane Washington USA"},{"name":"Washington State University Analytics &amp; Psychopharmacology Laboratory (APPL) Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. WHO report on the global tobacco epidemic 2023: protect people from tobacco smoke. Accessed July 8 2025.https:\/\/iris.who.int\/bitstream\/handle\/10665\/372043\/9789240077164-eng.pdf?sequence=1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490290087974"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874473711306010009"},{"key":"e_1_2_8_5_1","unstructured":"WHO.2018. Global status report on alcohol and health. Accessed July 8 2025.https:\/\/iris.who.int\/bitstream\/handle\/10665\/274603\/9789241565639-eng.pdf"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490050172218"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363232"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.08.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"issue":"20","key":"e_1_2_8_10_1","first-page":"22","article-title":"The Mini\u2010International neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10062"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.70075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T21:12:57Z","timestamp":1767042777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.70075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ajad.70075"],"URL":"https:\/\/doi.org\/10.1111\/ajad.70075","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}