{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:21:03Z","timestamp":1790968863278,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>There are hardly any data from longitudinal studies on the prevalence of mental health disorders in patients in opioid agonist therapy (OAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Here we report prevalence rates of mental health disorders in a 6\u2010year naturalistic noninterventional follow\u2010up study of patients in OAT (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20092694 at baseline).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of participants without any psychiatric diagnosis only modestly increased from 36.7% to 42.2% (males 42.6%, females 47.6%) over a 6\u2010year period. Depression (42%), anxiety disorders (19.3%), sleep disorders (21.3%), and posttraumatic stress disorder (13%) were most frequent. The rates for patients in psychiatric or psychological\/psychotherapeutic treatment at baseline were rather low (8% resp. 8\u201312%) and declined over time (3.6% resp. 5.4%\u20136.8% after 6 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Scientific Significance<\/jats:title>\n                    <jats:p>Data from this long\u2010term study indicate an overall high persisting prevalence of mental health disorders in patients in OAT and a rather low number of patients in psychiatric\/psychological treatment. Hence, this study indicates a substantial need for specific psychosocial and psychopharmacological interventions in patients in opioid agonist therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajad.70085","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:52:12Z","timestamp":1757911932000},"page":"90-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Persisting high rates of mental health disorders in patients in opioid agonist treatment\u2014Results from a 6\u2010year longitudinal study"],"prefix":"10.1111","volume":"35","author":[{"given":"Michael","family":"Soyka","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Psychiatric Hospital University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-5051","authenticated-orcid":false,"given":"Gabi","family":"Koller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Psychiatric Hospital University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wittchen","family":"Hans\u2010Ulrich","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Psychiatric Hospital University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"B\u00fchringer","sequence":"additional","affiliation":[{"name":"Department of Psychology Technical University of Dresden Munich Germany"},{"name":"Institut f\u00fcr Therapieforschung LMU University Hospital, LMU Munich M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32229-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000635"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.06.020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950010008002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-017-0074-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108996"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10550490903205652"},{"key":"e_1_2_8_9_1","first-page":"59","article-title":"Psychiatric comorbidity among patients on methadone maintenance therapy and its influence on quality of life","volume":"25","author":"Fei JTB","year":"2016","journal-title":"Am J Addict"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1412934"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"5","article-title":"Psychiatric comorbidity in substitution treatment of opioid\u2010dependent patients in primary care: prevalence and impact on clinical features","volume":"12","author":"Lieb M","year":"2010","journal-title":"Heroin Addict Relat Clin Probl"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000468518"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40429-025-00642-x"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.70085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T21:12:58Z","timestamp":1767042778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.70085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,14]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ajad.70085"],"URL":"https:\/\/doi.org\/10.1111\/ajad.70085","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,14]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}