{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:48:42Z","timestamp":1788547722705,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Childhood maltreatment (CM) significantly increases the risk of depression in patients with methamphetamine use disorder (MAUD). However, the underlying psychological mechanism remains unclear. The purpose of this study was to explore whether impulsivity mediates the relationship between CM and depression in patients with MAUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 577 Chinese male inpatients with MAUD. CM, depression, and impulsivity were assessed using standardized questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 321 of 577 (55.63%) patients with MAUD had experienced at least one form of CM. Maltreated patients exhibited elevated impulsivity and severe depression compared to nonmaltreated patients (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). CM, impulsivity, and depression were significantly interrelated (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). In addition, impulsivity partially mediated the CM\u2010depression link in patients with MAUD (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009.015, 95% CI [0.007, 0.026]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that CM has a long\u2010term effect on depression, and impulsivity is an essential contributor to depressive symptoms in patients with MAUD who have experienced CM. Future research should investigate these associations using multimodal approaches and assess focused interventions that may reduce impulsivity and mitigate the psychological impact of adverse childhood experiences (ACEs) in patients with MAUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Scientific Significance<\/jats:title>\n                    <jats:p>We identified impulsivity as a key mechanism in the CM\u2010depression link, offering a novel intervention target. Our findings advance the understanding of the psychological mechanisms in addiction psychiatry and suggest that interventions targeting impulsivity may help mitigate depression in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajad.70102","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:06:09Z","timestamp":1761894369000},"page":"370-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The mediating role of impulsivity in the relationship between childhood maltreatment and depression in methamphetamine patients"],"prefix":"10.1111","volume":"35","author":[{"given":"Saad","family":"Ullah","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0946-4624","authenticated-orcid":false,"given":"Arsalan","family":"Haider","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur Rab Tariq","family":"Kiyani","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"MianYang Teachers' College, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Huang","sequence":"additional","affiliation":[{"name":"MianYang Teachers' College, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-3734","authenticated-orcid":false,"given":"Xiang\u2010Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychological and Cognitive Sciences Tsinghua University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","article-title":"Methamphetamine use: a narrative review of adverse effects and related toxicities","volume":"10","author":"Edinoff AN","year":"2022","journal-title":"Health Psychol Res"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2022.107431"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsaa160"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abrep.2023.100488"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.13476"},{"key":"e_1_2_8_7_1","unstructured":"National Institute of Mental Health (NIMH)Depression;2024.https:\/\/www.nimh.nih.gov\/health\/topics\/depression"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211850"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2023.108716"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140097"},{"key":"e_1_2_8_11_1","unstructured":"RobertsonS.Drug abuse and depression. 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