{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:11:37Z","timestamp":1783530697610,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25\u2010year\u2010old woman with OUD, chronic pain, and major depressive disorder underwent an 8\u2010week protocol of intravenous ketamine infusions (0.5\u2009mg\/kg weekly) as an adjunct to opioid tapering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Methadone dosage was reduced by 50%, with improved pain and craving control, reduced withdrawal symptoms, and greater psychotherapy engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Ketamine\u2010assisted \u201cbridge therapy\u201d treatment may support opioid tapering in complex cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Scientific Significance<\/jats:title>\n                    <jats:p>This is a novel report to document a multifaceted improvement in this specific comorbidity cluster.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajad.70131","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:30:42Z","timestamp":1769668242000},"page":"431-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brief report: Ketamine\u2010assisted \u201cbridge therapy\u201d for opioid tapering in complex cases"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-3716","authenticated-orcid":false,"given":"Mariana C.","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia C.","family":"de Araujo Palmeira","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 B.","family":"Negr\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad A.","family":"Hadi","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia R.","family":"Arana","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"de C\u00e1ssia Ferreira Duarte","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joice L. P.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo K.","family":"Matsui","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o F. D.","family":"Rapozero","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas H.","family":"Crispim","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Malbergier","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o M.","family":"Castaldelli\u2010Maia","sequence":"additional","affiliation":[{"name":"Instituto Perdizes (IPER), Department of Psychiatry Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo S\u00e3o Paulo 05021\u2010001 S\u00e3o Paulo Brazil"},{"name":"Department of Psychiatry Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0137-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"e_1_2_10_4_1","article-title":"The impact of chronic pain and depression on medication for opioid use disorder treatment: a mixed\u2010methods analysis","volume":"26","author":"Kacmarek CN","year":"2024","journal-title":"Heroin Addict Relat Clin Probl"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200205000-00040"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.09.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-067194"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1552084"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2007.10399860"},{"issue":"8","key":"e_1_2_10_10_1","first-page":"625","article-title":"Effects of ketamine on precipitated opiate withdrawal","volume":"42","author":"Jovaisa T","year":"2006","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.05.016"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.70131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajad.70131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:22:03Z","timestamp":1777476123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/ajad.70131"],"URL":"https:\/\/doi.org\/10.1111\/ajad.70131","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}