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This umbrella review synthesized evidence on the associations between a broad range of social determinants of health (SDoH) and OUD\/overdose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An umbrella review of meta\u2010analyses and reviews on SDoH and OUD\/overdose was conducted using PubMED, PsycINFO, Embase, and Web of Science. A total of 29 reviews were deemed appropriate for inclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adverse childhood experiences and unemployment were associated with OUD outcomes. In the United States, immigrant status was associated with a lower risk of OUD, though this risk increased in subsequent generations. Individuals who experienced intimate partner violence and sexual minority individuals showed high prevalence of OUD. For overdose, associations were found in unemployment, low income, high poverty, and justice system involvement. Significant increases in odds of overdose were noted among individuals experiencing homelessness, lacking private insurance, engaging in sex work for pay, or witnessing an overdose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>This study identified SDoH associated with OUD outcomes and overdose risk, with findings having implications from a public health perspective for clinical practice, public health policy, and research priorities. There is a need for meta\u2010analyses to clarify the magnitude of SDoH influences on OUD\/overdose, with the goal of informing targeted interventions to reduce opioid\u2010related morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Scientific Significance<\/jats:title>\n                    <jats:p>The most comprehensive umbrella review to date on intersections among SDoH, OUD outcomes, and overdose risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajad.70133","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:36:57Z","timestamp":1770781017000},"page":"339-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations among social determinants of health and opioid use disorder and overdose: An umbrella review"],"prefix":"10.1111","volume":"35","author":[{"given":"Lauren B.","family":"Loeffel","sequence":"first","affiliation":[{"name":"VA Boston Healthcare System Boston Massachusetts USA"},{"name":"Department of Psychiatry Boston University Chobanian &amp; Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Rim","family":"Kwak","sequence":"additional","affiliation":[{"name":"NYC Health+Hospitals\/Harlem New York New York USA"},{"name":"Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghyun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Maimonides Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Yale College Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9878-9633","authenticated-orcid":false,"given":"Dylan J.","family":"Jester","sequence":"additional","affiliation":[{"name":"War Related Illness and Injury Study Center (WRIISC) VA Palo Alto Health Care System Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dawes","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System Boston Massachusetts USA"},{"name":"Department of Psychiatry Boston University Chobanian &amp; Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold S.","family":"Kudler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences Duke University School of Medicine Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip V.","family":"Jeste","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Network La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Jongho","family":"Na","sequence":"additional","affiliation":[{"name":"VA Connecticut Healthcare System West Haven Connecticut USA"},{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadr.2022.100052"},{"key":"e_1_2_9_3_1","unstructured":"SpencerMR GarnettMF Mini\u00f1oAM. 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