{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:41:10Z","timestamp":1777351270741,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K23DA052682"],"award-info":[{"award-number":["K23DA052682"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Addict"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Once\u2010daily methadone dosing for opioid use disorder (OUD) may leave periods of inadequate analgesia. We tested whether experimental pain sensitivity differs across the inter\u2010dose interval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010five adults (52% female, 43.12 years old) with OUD receiving stable once\u2010daily methadone completed thermal quantitative sensory testing at early post\u2010dose and pre\u2010dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Heat pain threshold (MD \u22123.75\u00b0C;\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u2009\u22120.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and tolerance (MD \u22120.92\u00b0C;\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u2009\u22120.49;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018) were lower at pre\u2010dose. Temporal summation and conditioned pain modulation did not differ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Pain sensitivity increased pre\u2010dose, consistent with a hyperalgesic window.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Scientific Significance<\/jats:title>\n                    <jats:p>Preliminary experimental evidence that once\u2010daily methadone may contribute to cyclical hyperalgesia in persons with OUD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajad.70162","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:10:39Z","timestamp":1777349439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brief Report: Is once daily enough? Assessing the impact of timing of methadone dose on pain sensitivity via quantitative sensory testing in persons with opioid use disorder"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8702-5436","authenticated-orcid":false,"given":"Gabriel P. A.","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Clinical Neuroscience Research Unit (CNRU), Connecticut Mental Health Center (CMHC) New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Riggione","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Clinical Neuroscience Research Unit (CNRU), Connecticut Mental Health Center (CMHC) New Haven Connecticut USA"},{"name":"VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Meyerovich","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Clinical Neuroscience Research Unit (CNRU), Connecticut Mental Health Center (CMHC) New Haven Connecticut USA"},{"name":"VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan T.","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"APT Foundation New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-8215","authenticated-orcid":false,"given":"Joao P.","family":"De Aquino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Clinical Neuroscience Research Unit (CNRU), Connecticut Mental Health Center (CMHC) New Haven Connecticut USA"},{"name":"VA Connecticut Healthcare System West Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jpain.2022.08.008","article-title":"Systematic review and meta\u2010analysis of the prevalence of chronic pain among patients with opioid use disorder and receiving opioid substitution therapy","volume":"24","author":"Delorme J","year":"2023","journal-title":"J Pain"},{"issue":"2","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7326\/0003-4819-144-2-200601170-00010","article-title":"Acute pain management for patients receiving maintenance methadone or buprenorphine therapy","volume":"144","author":"Alford DP","year":"2006","journal-title":"Ann Intern Med"},{"issue":"4","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","DOI":"10.1097\/PR9.0000000000001016","article-title":"Central sensitization in opioid use disorder: a novel application of the American College of Rheumatology Fibromyalgia Survey Criteria","volume":"7","author":"Hall OT","year":"2022","journal-title":"PAIN Reports"},{"issue":"2","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.36076\/ppj.2011\/14\/145","article-title":"Manchikanti L. A comprehensive review of opioid\u2010induced hyperalgesia","volume":"14","author":"Lee M","year":"2011","journal-title":"Pain Physician"},{"issue":"1","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1067\/mcp.2003.5","article-title":"Analgesic effects of morphine and morphine\u20106\u2010glucuronide in a transcutaneous electrical pain model in healthy volunteers","volume":"73","author":"Skarke C","year":"2003","journal-title":"Clin Pharm Ther"},{"issue":"10","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1016\/j.neubiorev.2013.08.006","article-title":"The downward spiral of chronic pain, prescription opioid misuse, and addiction: cognitive, affective, and neuropsychopharmacologic pathways","volume":"37","author":"Garland EL","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"issue":"6","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1037\/pha0000039","article-title":"Pain volatility and prescription opioid addiction treatment outcomes in patients with chronic pain","volume":"23","author":"Worley MJ","year":"2015","journal-title":"Exp Clin Psychopharmacol"},{"issue":"1","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejpain.2005.02.003","article-title":"Quantitative sensory testing: a comprehensive protocol for clinical trials","volume":"10","author":"Rolke R","year":"2006","journal-title":"Eur J Pain"},{"key":"e_1_2_8_10_1","article-title":"Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open\u2010label, proof\u2010of\u2010concept study","volume":"23","author":"Costa GPA","year":"2026","journal-title":"Addict Behav Rep"},{"issue":"9","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13317","article-title":"Delta\u20109\u2010tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: a within\u2010subject, randomized, placebo\u2010controlled laboratory study","volume":"28","author":"De Aquino JP","year":"2023","journal-title":"Addict Biol"}],"container-title":["The American Journal on Addictions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.70162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajad.70162","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajad.70162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:10:45Z","timestamp":1777349445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.70162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":10,"alternative-id":["10.1111\/ajad.70162"],"URL":"https:\/\/doi.org\/10.1111\/ajad.70162","archive":["Portico"],"relation":{},"ISSN":["1055-0496","1521-0391"],"issn-type":[{"value":"1055-0496","type":"print"},{"value":"1521-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ajad.70162"}}