{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:38:20Z","timestamp":1785587900613,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the incidence of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) in aged patients receiving empiric gentamicin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients aged \u226565 years receiving gentamicin upon admission between 2013 and 2015 at two Australian hospitals were retrospectively studied. <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was defined as a rise in creatinine by \u226550% and\/or \u226526.5 \u03bcmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients (95%) received a single dose of gentamicin. The incidence of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was 15% (36\/242 patients). A composite outcome of persistent kidney injury, requirement for renal replacement therapy or inpatient death in a patient with <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> occurred in 10 (4%) patients. Patients who developed <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> were older (median 80.5 vs 78 years, P = 0.03), had higher Charlson Co\u2010morbidity Index (median 7 vs 5, P = 0.0004) and had more advanced chronic kidney disease at baseline (Stages <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and V) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.38, 95% confidence interval 1.45\u201313.2, P = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Empiric gentamicin use in patients with advancing age is associated with low rates of predominantly transient renal impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajag.12541","type":"journal-article","created":{"date-parts":[[2018,4,28]],"date-time":"2018-04-28T05:20:32Z","timestamp":1524892832000},"page":"227-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Renal safety of short\u2010term empiric gentamicin therapy in aged patients"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8540-6813","authenticated-orcid":false,"given":"Christopher SB","family":"Sia","sequence":"first","affiliation":[{"name":"Department of General Medicine Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle R","family":"Ananda\u2010Rajah","sequence":"additional","affiliation":[{"name":"Department of General Medicine Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases Alfred Hospital Melbourne Victoria Australia"},{"name":"Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki R","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of General Medicine Alfred Hospital Melbourne Victoria Australia"},{"name":"School of Public Health and Preventative Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baey","family":"Yi\u2010Wei","sequence":"additional","affiliation":[{"name":"Department of General Medicine Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Liew","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Y","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of General Medicine Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Pharmacy Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ar Kar","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of General Medicine Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Infectious 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