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Including PIMs\u2013interactions, therapeutic alternatives and the clinical management of PIMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic scoping review was conducted in PubMed and Scopus (until May 2021). The number of PIMs listed as essential drugs was identified in <jats:italic>Model List of Essential Medicines<\/jats:italic> by the World Health Organization (WHO) and <jats:italic>National List of Essential Medicines<\/jats:italic> (Brazil). In addition to reporting the therapeutic alternatives and clinical management proposed by explicit screening tools to identify PIMs, we suggested our own alternatives for the PIMs most frequently reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight tools reported 614 PIMs and 747 PIMs\u2013interactions. Limited overlap between the tools was observed: 123 (69.1%) of 178 therapeutic alternatives proposed by the tools were considered inappropriate by other tools, and 222 (36.1%) of the 614 PIMs identified were named as being inappropriate only once. Only 21 tools were developed by a Delphi panel technique associated with systematic review. The PIMs listed as essential medication in Brazil and by the WHO were 30.6% and 23.3% of the total reported, respectively. For the most\u2010cited PIMs, such as non\u2010steroidal anti\u2010inflammatory drugs, tricyclic antidepressants and benzodiazepines, we suggested the use of non\u2010opioid and opioid analgesics; agomelatine, bupropion or moclobemide; and melatonin, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The next stages in the development of explicit screening tools to identify PIMs include achieving more consensus between them and improving their applicability across countries. 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