{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:02:13Z","timestamp":1784383333311,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Among residents who had a residential medication management review (RMMR), there is a lack of studies assessing exposure to polypharmacy and potentially inappropriate medications (PIMs) in people with dementia. This study compared the exposure to polypharmacy and PIMs in residents with dementia and without dementia receiving RMMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was performed using data of 16,261 residents living in 343 Australian residential aged care facilities who had an RMMR in 2019. Medication use was assessed as polypharmacy (defined as \u22659 medications) and use of \u22651 PIMs using the 2019 updated Beers criteria. Dementia diagnosis was determined with ICD\u201010 coding from medical records. Descriptive analyses reported resident demographics and patterns of medication use. Pearson's <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> tests and logistic regression analysis were conducted to compare medication exposure between residents with and without dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 16,261 residents, 6781 (42%) had dementia. Residents with dementia were significantly more likely to be exposed to polypharmacy and PIMs, compared to those without dementia (74% vs. 70% and 83% vs. 73%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 respectively). Residents with dementia had 1.31 times the odds of exposure to polypharmacy (adjusted OR: 1.31, 95% CI: 1.22\u20131.41, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and 1.88 times the odds of being prescribed \u22651 PIMs than people without dementia (adjusted OR: 1.88, 95% CI: 1.73\u20132.04, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a study of residents receiving RMMR, polypharmacy and PIMs were highly common, and those with dementia were more likely to be exposed to inappropriate polypharmacy. There is a need for targeted deprescribing strategies to immediately address inappropriate prescribing in residents, particularly those living with dementia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajag.13316","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T16:58:10Z","timestamp":1712422690000},"page":"628-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of polypharmacy and potentially inappropriate medication use in older adults with and without dementia receiving residential medication management reviews"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-3524","authenticated-orcid":false,"given":"Mouna J.","family":"Sawan","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Pharmacy School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Clough","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Pharmacy School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Hillen","sequence":"additional","affiliation":[{"name":"University of South Australia  Adelaide South Australia Australia"},{"name":"Ward Medication Management  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Soulsby","sequence":"additional","affiliation":[{"name":"Ward Medication Management  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Gnjidic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Pharmacy School The University of Sydney  Sydney New South Wales Australia"},{"name":"Charles Perkins Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1961576"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098616670798"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1497156"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.09.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.10.027"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12757"},{"key":"e_1_2_11_8_1","volume-title":"Residential Medication Management Review and Quality Use of Medicines","author":"Pharmacy Programs Administrator","year":"2018"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12676"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12827"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac149"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/11316440-000000000-00000"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-022-07825-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-016-0357-2"},{"key":"e_1_2_11_15_1","volume-title":"RACGP Aged Care Clinical Guide (Silver Book) Part B. 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